{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:03:21Z","timestamp":1759961001698},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T00:00:00Z","timestamp":1075420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p><jats:bold>Abstract<\/jats:bold>  <jats:bold>\n            <jats:italic>Background<\/jats:italic>\n          <\/jats:bold>: Non\u2010operative management for patients with fistula\u2010in\u2010ano in infancy using a traditional herbal medicine Ginseng and Tang\u2010kuei Ten Combination (GTTC) is described.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Methods<\/jats:italic>\n          <\/jats:bold>: A total of 22 patients with peri\u2010anal abscess or fistula\u2010in\u2010ano were treated with GTTC. Eighteen patients showed no improvement using the conventional non\u2010operative management (frequent curettage of abscess cavity), after which administration of GTTC was commenced. The other four patients received GTTC from the beginning of their treatment. A dose of 0.1\u22120.2\u2003g\/kg of GTTC was given orally twice a day. The period between onset of peri\u2010anal abscess and the commencement of GTTC (pre\u2010GTTC period) was compared to the period until remission after administration of GTTC (post\u2010GTTC period). The relationship between the GTTC dose, age at onset of peri\u2010anal abscess, post\u2010GTTC period, and relapse rates were investigated.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Results<\/jats:italic>\n          <\/jats:bold>: Twenty\u2010one patients reached remission, but a 4\u2010year\u2010old boy failed to reach remission and he required fistelectomy. Pre\u2010GTTC periods were from 11 days to 3 years (median 50 days) and statistically longer than post\u2010GTTC periods (4\u221265 days, median 7 days). There was a reverse correlation between the age at onset of peri\u2010anal abscess and post\u2010GTTC period (<jats:italic>r<\/jats:italic>\u2003=\u2003\u2212044, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). There was no statistical correlation between the dose of GTTC and post\u2010GTTC period. Five patients showed relapse after discontinuing GTTC, all of them could be resolved with augmentation of the dose. The onset of peri\u2010anal abscess in patients who relapsed were all &lt; 3 months of age.<\/jats:p><jats:p> <jats:bold>\n            <jats:italic>Conclusion<\/jats:italic>\n          <\/jats:bold>: Ginseng and Tang\u2010kuei Ten Combination seemed to accelerate the recovery of patients with fistula\u2010in\u2010ano in infancy.<\/jats:p>","DOI":"10.1111\/j.1442-200x.2004..x","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T16:44:28Z","timestamp":1075481068000},"page":"72-76","source":"Crossref","is-referenced-by-count":12,"title":["Management for fistula\u2010in\u2010ano with Ginseng and Tang\u2010kuei Ten Combination"],"prefix":"10.1111","volume":"46","author":[{"given":"Toshiki","family":"Ohya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Arii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,30]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"217","volume-title":"Kampo. Japanese\u2010Oriental Medicine. Insights from Clinical Cases.","author":"Terasawa K","year":"1993"},{"key":"e_1_2_5_3_2","first-page":"461","article-title":"Effect of Juzentaihoto on phagocytes","volume":"8","author":"Maruyama H","year":"1988","journal-title":"Jpn. J. Inflamm."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00199765"},{"key":"e_1_2_5_5_2","first-page":"191","article-title":"A traditional Chinese herbal medicine, Juzen\u2010taiho\u2010to, augments the production of granulocyte\/macrophage colony\u2010stimulating factor from human peripheral blood mononuclear cells in vitro","volume":"8","author":"Kubota A","year":"1992","journal-title":"Int. J. Immunother."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(00)80070-7"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(88)90160-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1996.tb03107.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.677"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.6.1000"},{"key":"e_1_2_5_11_2","first-page":"1305","article-title":"Basal studies on combination of Chinese medicine in the cancer chemotherapy: Protective effects of on the toxic side effects of CDDP and antitumor effects with CDDP on murine bladder tumor (MBT\u20102)","volume":"24","author":"Ebisuno S","year":"1989","journal-title":"J. Jpn. Soc. Cancer Ther."},{"key":"e_1_2_5_12_2","first-page":"1494","article-title":"Preventive effects of TJ\u201048 on recovery from radiation injury","volume":"16","author":"Ohnishi Y","year":"1989","journal-title":"Jpn J. Cancer Chemother."},{"key":"e_1_2_5_13_2","first-page":"501","article-title":"Internal anal sphincter and anorectal abscess","volume":"103","author":"Eisenhammer S","year":"1956","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80399-7"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80327-5"},{"key":"e_1_2_5_16_2","first-page":"1123","article-title":"Periproctal abscess and anal fistula in infancy","volume":"21","author":"Nambu K","year":"1985","journal-title":"J. Jpn. Soc. Pediatr. Surg."},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.25.1"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050315"},{"key":"e_1_2_5_19_2","first-page":"737","article-title":"Fistula in ano in infants and children: implications and management","volume":"87","author":"Longo WE","year":"1991","journal-title":"Pediatrics"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1997.02699.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90193-2"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.26372"},{"key":"e_1_2_5_23_2","first-page":"177","volume-title":"Kampo. Japanese\u2010Oriental Medicine. Insights from Clinical Cases.","author":"Terasawa K","year":"1993"},{"key":"e_1_2_5_24_2","first-page":"1322","article-title":"The efficacy of Juzen\u2010taiho\u2010to for treatment of infantile perianal abscess","volume":"32","author":"Muramatsu T","year":"2000","journal-title":"Jpn J. Pediatr. Surg."}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1442-200X.2004..x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1442-200X.2004..x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:17:20Z","timestamp":1696922240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1442-200X.2004..x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,30]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1111\/j.1442-200X.2004..x"],"URL":"https:\/\/doi.org\/10.1111\/j.1442-200x.2004..x","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,30]]}}}