{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:55:26Z","timestamp":1790751326948,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Glucagon\u2010like peptide\u20102 (GLP\u20102) arises from proglucagon within enteroendocrine L cells of the small and large intestines, and its physiological roles have been gradually elucidated. However, the circulating GLP\u20102 levels in human neonates are still unknown. The aim of the present study was to measure serum GLP\u20102 levels in extremely low\u2010birthweight (ELBW) infants and normal\u2010term infants, and to compare these values between the two groups.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Blood samples were collected and serum GLP\u20102 concentrations measured, from 15 ELBW infants at three stages (stage I, before initial feeding after birth; stage II, point at which milk intake reached 100 mL\/kg per day; stage III, corrected 40 weeks of gestation), and from 30 normal\u2010term infants at two stages (stages I and II).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> No significant difference in basal GLP\u20102 values at stage I (before initial feeding) was found between ELBW infants and normal\u2010term infants (7.37 \u00b1 0.95 ng\/mL<jats:italic> vs <\/jats:italic>9.47 \u00b1 0.94 ng\/mL). However, in ELBW infants, serum GLP\u20102 concentrations at stage II were significantly increased, compared with those at stage I (<jats:italic>P <\/jats:italic>&lt; 0.0001). In normal\u2010term infants, serum GLP\u20102 concentrations at stage II were also significantly increased compared with those at stage I (<jats:italic>P <\/jats:italic>&lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The results suggest that initial feeding stimulates secretion of serum GLP\u20102 in neonates. In addition, the secretion mechanism of GLP\u20102 is considered to be established at 24 weeks of gestation at the latest.<\/jats:p>","DOI":"10.1111\/j.1442-200x.2006.02255.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T13:04:37Z","timestamp":1158066277000},"page":"464-469","source":"Crossref","is-referenced-by-count":9,"title":["Serum glucagon\u2010like peptide\u20102 levels in neonates: Comparison between extremely low\u2010birthweight infants and normal\u2010term infants"],"prefix":"10.1111","volume":"48","author":[{"given":"HIDEKI","family":"YOSHIKAWA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ICHIRO","family":"MIYATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIKATSU","family":"ETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.257"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.2.7983"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.6.0385"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.428"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00095-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.063"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0015"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7911"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00136-2"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2884"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31068"},{"key":"e_1_2_5_13_2","first-page":"A74A","article-title":"Nutrient stimulated GLP\u20102 release and crypt cell production in experimental short bowel syndrome","volume":"17","author":"Martin GR","year":"2003","journal-title":"Can. 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