{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:28:52Z","timestamp":1793125732099,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:00:00Z","timestamp":1343260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mild encephalitis\/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza\u2010associated encephalopathy. There was no elevation of Interleukin (IL)\u20101\u03b2, which induces convulsion. The inhibitory cytokines of IL\u201010 and IFN\u2010\u03b3 were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL\u201010 and IFN\u2010\u03b3 might work to localize the lesion and to prevent sequelae.<\/jats:p>","DOI":"10.1111\/j.1442-200x.2011.03483.x","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T06:25:41Z","timestamp":1343283941000},"page":"536-538","source":"Crossref","is-referenced-by-count":25,"title":["High production of interleukin\u201010 and interferon\u2010\u03b3 in influenza\u2010associated MERS in the early phase"],"prefix":"10.1111","volume":"54","author":[{"given":"Shinichiro","family":"Morichi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ioi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Hoshika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,26]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00809.x"},{"key":"e_1_2_4_3_2","first-page":"1","volume-title":"[2000\u20132002 General Report of the Research Committee for Research on Emerging and Re\u2010Emerging Diseases.]","author":"Morishima T","year":"2003"},{"key":"e_1_2_4_4_2","first-page":"156","article-title":"Transient splenial lesion of the corpus callosum in clinically mild influenza\u2010associated encephalitis\/encephalopathy","volume":"27","author":"Bulakbasi N","year":"2006","journal-title":"Am. 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