{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:26:21Z","timestamp":1792585581189,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the feasibility of small intestinal submucosa graft for the repair of selected anterior urethral strictures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2009 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2011, 28 men (mean age 39 years) with anterior urethral strictures underwent urethroplasty using a four\u2010layer small intestinal submucosa patch graft in an onlay or inlay fashion. The stricture was localized to the bulbar urethra in eight patients, the bulbopenile area in nine patients and the distal penile urethra in 10 patients. Failed hypospadias was observed in one patient. The mean stricture length was 4.6\u2009cm (range 3.5\u20137.0\u2009cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period was 24.8 months (range 12\u201330 months). No postoperative complications, such as infection or rejection, were related to the use of heterologous graft material. The patients voided well postoperatively, with peak flows between 16 and 44\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/s (mean 25.4\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/s) in 26 patients. Two patients (7.1%) developed a urethral narrowing; this occurred at 5 months in one patient and 6 months in the other, and cystoscopy, which was carried out at 20 and 24 weeks, respectively, showed clear cicatricial tissue at the proximal anastomotic site. Dilation was carried out once every 4\u20136 months for recurrent stricture in one patient and lingual mucosal graft urethroplasty was carried out in the other patient at 18 months postoperatively. Biopsies were obtained in four patients at 18, 24, 36 and 42 weeks, respectively. Squamous epithelium with or without hyperkeratosis was observed on histological examination of the small intestinal submucosa\u2010grafted areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The small intestinal submucosa matrix appears to be a safe and effective reconstructive material for selective use in urethral reconstructive surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1442-2042.2012.03230.x","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T07:06:33Z","timestamp":1352271993000},"page":"622-629","source":"Crossref","is-referenced-by-count":15,"title":["Outcome of small intestinal submucosa graft for repair of anterior urethral strictures"],"prefix":"10.1111","volume":"20","author":[{"given":"Yue\u2010Min","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Long","family":"Sa","sequence":"additional","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology, Sixth People's Hospital Jiaotong University of Shanghai  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007071"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.030"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-009-0378-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64060-8"},{"key":"e_1_2_8_6_1","first-page":"405","article-title":"Small intestinal submucosa (SIS): prospects in urogenital surgery","volume":"15","author":"Dedecker F","year":"2005","journal-title":"Prog. 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