{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:54:42Z","timestamp":1792709682275,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> To study the long\u2010term efficacy and safety of diode laser cycloablation under a standard protocol in refractory glaucoma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A retrospective study involving 42 eyes (39 patients), observed for 36\u201384 (mean 65.7) months after cycloablation involving 14 burns of 2\u2010W power and 2\u2010s duration, over 270\u00b0 of the ciliary body.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> By final review, mean intraocular pressure (IOP) had dropped by 50.3% from 31.4\u2003\u00b1\u20038.8\u2003mmHg before treatment to 15.6\u2003\u00b1\u20036.3\u2003mmHg (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Thirty\u2010seven of the 42 eyes (88.1%) achieved IOP\u2003&lt;\u200322\u2003mmHg. Thirty\u2010five of the 42 eyes (83.3%) eyes achieved IOP reduction\u2003\u2265\u200330% from baseline levels. The mean number of antiglaucoma medications per eye dropped from 2.55\u2003\u00b1\u20030.83 to 1.71\u2003\u00b1\u20031.44 (<jats:italic>P<\/jats:italic>\u2003=\u20030.0004). The percentage of eyes requiring oral acetazolamide dropped from 92.9% to 11.9% (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). About 59.6% of eyes required multiple treatment sessions (mean 2.17). Twenty\u2010seven (64.3%) eyes suffered deterioration, 11 (26.2%) maintained stability and 4 (9.5%) exhibited improvement of visual acuity. No relationship between the number of treatment sessions and visual outcome was evident.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This conservative repeatable protocol affords delivery of the minimum dose of photocoagulation necessary to achieve a safe, long\u2010term ocular hypotensive response, while minimizing the risk of serious adverse effects, and is valuable in the difficult treatment of refractory glaucoma.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01241.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T09:08:40Z","timestamp":1152695320000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Diode laser cycloablation in adult glaucoma: long\u2010term results of a standard protocol and review of current literature"],"prefix":"10.1111","volume":"34","author":[{"given":"Stephen A","family":"Vernon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M","family":"Koppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Jayakrishna","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75758-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090040080035"},{"key":"e_1_2_5_4_2","first-page":"225","article-title":"Initial experience with a new method of transscleral cyclophotocoagulation for ciliary ablation in severe glaucoma","volume":"90","author":"Gaasterland DE","year":"1992","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_5_2","first-page":"2774","article-title":"A comparison of neodymium:yttrium aluminium garnet and diode laser trans\u2010scleral cyclophotocoagulation and cyclocryotherapy","volume":"32","author":"Assia EI","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_6_2","first-page":"1586","article-title":"Histopathology of continuous wave neodymium:yttrium aluminium garnet and diode laser contact laser trans\u2010scleral lesions in rabbit ciliary body. 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