{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:57:27Z","timestamp":1780631847224,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> To observe the effect of intraoperative mitomycin C of varying concentration on postoperative ostium size after external dacryocystorhinostomy (DCR).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In this prospective controlled study, 60 cases of DCR were taken up irrespective of age and sex. Cases were divided into three groups. Group 1 was taken as a control group and operated without mitomycin C; in experimental group 2 and group 3, mitomycin C at a concentration of 0.05\u2003mg\/mL and 0.4\u2003mg\/mL was applied, respectively, for 2\u2003min. Each group consisted of 20 cases. Half of the cases in each group underwent single\u2010flap DCR (SFDCR) and half underwent double\u2010flap DCR (DFDCR) surgery. Nasal endoscopic evaluation was performed on the first postoperative day, at 2\u2003weeks and at 6\u2003months after surgery. A Student\u2019s <jats:italic>t<\/jats:italic>\u2010test was used to compare the osteotomy size of each group.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> At the end of the final follow up, average size of the ostium in group 1 was 3.6\u2003\u00b1\u20032.36\u2003mm<jats:sup>2<\/jats:sup> in SFDCR and 4.5\u2003\u00b1\u20033.59\u2003mm<jats:sup>2<\/jats:sup> in DFDCR, in group 2 was 4.8\u2003\u00b1\u20034.82\u2003mm<jats:sup>2<\/jats:sup> in SFDCR and 4.9\u2003\u00b1\u20034.12\u2003mm<jats:sup>2<\/jats:sup> in DFDCR, and in group 3 was 16.6\u2003\u00b1\u20036.80\u2003mm<jats:sup>2<\/jats:sup> in SFDCR and 17.5\u2003\u00b1\u20039.07\u2003mm<jats:sup>2<\/jats:sup> in DFDCR. The ostium size in group 3 was found to be significantly bigger in comparison with group 1 (<jats:italic>P<\/jats:italic>\u2003=\u20030.0001 in SFDCR, <jats:italic>P<\/jats:italic>\u2003=\u20030.001 in DFDCR) and with group 2 (<jats:italic>P<\/jats:italic>\u2003=\u20030.0009 in SFDCR, <jats:italic>P<\/jats:italic>\u2003=\u20030.001 in DFDCR). No statistically significant difference of ostium size was found in SFDCR and DFDCR.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Mitomycin C in appropriate dose minimizes postoperative fibrosis and granulations, thereby maintaining a bigger postoperative ostium throughout the postoperative observation period.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01265.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T08:58:57Z","timestamp":1152694737000},"page":"557-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Effect of mitomycin C on ostium in dacryocystorhinostomy"],"prefix":"10.1111","volume":"34","author":[{"given":"Amarendra","family":"Deka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasturi","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh Kr","family":"Bhuyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiranjib Kumar","family":"Barua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautom","family":"Khaund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105470"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.048033"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200103000-00007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.903"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065800782102672"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.2.200"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.12.888"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20010501-08"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.7.790"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(49)90973-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76532-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(61)92098-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.45.2.117"},{"key":"e_1_2_6_15_2","first-page":"601","article-title":"Results of dacryocystorhinostomy, analysis of causes of failure","volume":"93","author":"Welham RAN","year":"1973","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30357-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040738005"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.7.786"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1442-9071.2006.01265.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1442-9071.2006.01265.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:38:57Z","timestamp":1696912737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1442-9071.2006.01265.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,12]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1442-9071.2006.01265.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1442-9071.2006.01265.x","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,12]]},"assertion":[{"value":"2006-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}