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When detected early, POAG is amenable to therapeutic intervention. Unfortunately, current population\u2010based clinical screening lacks efficacy. If individuals with a genetic predisposition for developing POAG can be identified, then efficient and cost\u2010effective population\u2010based screening programs could be designed. Although considerable inroads have been made in understanding the natural history of POAG caused by mutations in the <jats:italic>myocilin<\/jats:italic> and <jats:italic>optineurin<\/jats:italic> genes, other POAG genes accounting for most cases remain to be identified. This review explores the genetic mechanisms that have been unequivocally linked to the glaucomatous process and then discusses potential avenues for future breakthroughs.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01268.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T09:08:40Z","timestamp":1152695320000},"page":"472-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Complex genetics of complex traits: the case of primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"34","author":[{"given":"Alex W","family":"Hewitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.5.389"},{"key":"e_1_2_12_3_2","first-page":"844","article-title":"Global data on visual impairment in the year 2002","volume":"82","author":"Resnikoff S","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.238"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.50.10.570"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.7.835"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.042"},{"key":"e_1_2_12_8_2","first-page":"1661","article-title":"Prevalence of open\u2010angle glaucoma in Australia","volume":"103","author":"Mitchell P","year":"1996","journal-title":"The Blue Mountains Eye Study Ophthalmol"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)94031-3"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01040-0"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.04.018"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/09286589709058056"},{"key":"e_1_2_12_13_2","first-page":"389","article-title":"Screening for glaucoma","volume":"5","author":"Harris R","year":"2005","journal-title":"BMJ USA"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02720732"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011203032104"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(03)00066-X"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(03)00062-2"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.11.9.438"},{"key":"e_1_2_12_19_2","first-page":"448","volume-title":"The Treasury of Human Inheritance. 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