{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:14:24Z","timestamp":1791137664334,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> One definite, one probable and several possible transmissions of sporadic Creutzfeldt\u2013Jakob disease (sCJD) have followed corneal transplantation. We report an incident in the UK in 1997 in which both corneas and scleras from a donor, subsequently confirmed to have had sCJD, were transplanted. The final clinical outcome for two surviving recipients is still not yet known.<\/jats:p><jats:p><jats:bold>Case report:\u2002<\/jats:bold> In 1997, a 56\u2010year\u2010old woman died from biopsy\u2010proven carcinoma of the bronchus. Both eyes were donated for transplantation. Shortly before she died, she had developed neurological symptoms thought to be due to brain metastases. However, the final result of a neurological post\u2010mortem examination revealed evidence of sCJD. By this time the corneas had been transplanted, one 3\u2003months previously into a 40\u2010year\u2010old man for keratoconus and the other 4\u2003months previously into an 85\u2010year\u2010old woman for Fuchs\u2019 dystrophy. In addition, both scleras had been transplanted into a 36\u2010year\u2010old man undergoing oculoplastic reconstructive surgery. The surgeons and patients were informed and removal of tissue was advised but undertaken in only two of the patients. Immunohistochemistry failed to demonstrate the presence of the abnormal form of the prion protein in explanted tissue.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Eight years after the event, two patients remain free of symptoms suggestive of iatrogenic CJD (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.cjd.ed.ac.uk\/criteria.htm\">http:\/\/www.cjd.ed.ac.uk\/criteria.htm<\/jats:ext-link>). The third having died aged 92\u2003years, some 7\u2003years after surgery, showing signs of dementia not considered indicative of iatrogenic CJD. Nevertheless this adverse incident attracted substantial publicity. Coupled with continuing concerns in the UK about person\u2010to\u2010person transmission of variant CJD, this has lead to a number of important consequences in donor eye retrieval, ocular tissue banking and transplantation.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01308.x","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T10:30:48Z","timestamp":1155119448000},"page":"645-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transplantation of ocular tissue from a donor with sporadic Creutzfeldt\u2013Jakob disease"],"prefix":"10.1111","volume":"34","author":[{"given":"Andrew B","family":"Tullo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W John","family":"Armitage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W","family":"Ironside","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403212901220"},{"key":"e_1_2_5_3_2","first-page":"465","volume-title":"Prion Biology and Diseases","author":"Will RG","year":"1999"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199511000-00002"},{"key":"e_1_2_5_5_2","first-page":"466","article-title":"An autopsy case of Creutzfeldt\u2010Jacob disease associated with corneal transplantation","volume":"8","author":"Uchiyama K","year":"1994","journal-title":"Dementia"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.3.388"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.637"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200405000-00019"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1075"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199901000-00002"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.5.721"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.028373"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05403-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-1273"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.063495"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.5.587"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00150-0"},{"key":"e_1_2_5_18_2","first-page":"S76","article-title":"Ocular tonometry and transmissible spongiform encephalopathy","volume":"147","author":"Davinapour Z","year":"1998","journal-title":"Am J Epidemiol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.583"},{"key":"e_1_2_5_20_2","first-page":"104","article-title":"The risk of transmision of variant CJD via contact lenses and ophthalmic devices Contact Lens and Ant","volume":"25","author":"Macalister GO","year":"2002","journal-title":"Eye"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.11.1360"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15486-X"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"}],"container-title":["Clinical &amp; 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