{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:40:45Z","timestamp":1697002845422},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The hospital\u2010based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open\u2010angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed. Main outcome measures were optic nerve head parameters, the development or progression of visual field defects and iris colour.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In most of the study groups, size of the optic disc, neuroretinal rim, alpha zone and beta zone of parapapillary atrophy, retinal vessel diameter and central corneal thickness did not differ significantly between eyes with blue, green, brown and mixed iris colour. In the normal\u2010pressure glaucoma group, neuroretinal rim area was smallest in the population with mixed\u2010coloured eyes and largest in the group of eyes with brown irides (<jats:italic>P<\/jats:italic>\u2003= 0.001 after correction for inter\u2010eye dependency and multiple testing). For the ocular hypertensive subjects and glaucoma patients with follow\u2010up examinations, the rate of development or progression of glaucomatous visual field loss was not significantly associated with iris colour (<jats:italic>P<\/jats:italic>\u2003= 0.060).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In Caucasian subjects, iris colour does not have a major association with the size of the optic nerve head structures, central corneal thickness and retinal arterial diameter. In Caucasian patients with ocular hypertension or chronic open\u2010angle glaucoma, an influence of iris colour on the risk for development or progression of glaucomatous visual field defects could not be confirmed.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01310.x","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T10:30:48Z","timestamp":1155119448000},"page":"654-660","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage"],"prefix":"10.1111","volume":"34","author":[{"given":"Jost B","family":"Jonas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wido M","family":"Budde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Stroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel M","family":"Oberacher\u2010Velten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(50)90841-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1976.tb01801.x"},{"key":"e_1_2_6_4_2","first-page":"1151","article-title":"Optic disc, cup and neuroretinal rim size, configuration, and correlations in normal eyes","volume":"29","author":"Jonas JB","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090200074026"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90457-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010858029"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199508000-00006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060120081030"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200110001-00007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(85)90001-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470030069026"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.532"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.1.22"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00049-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00223-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080140070030"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01098-9"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113629"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98013-7"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(85)90230-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00580-7"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.6.811"},{"key":"e_1_2_6_25_2","first-page":"545","article-title":"Optic disc size and iris colour","volume":"116","author":"Budde WM","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.714"}],"container-title":["Clinical &amp; 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