{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:37:13Z","timestamp":1790789833341,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:00:00Z","timestamp":1170806400000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p>The role of inflammation in the aetiology of age\u2010related macular degeneration (AMD) has become very topical as the discovery that genetic variation in complement pathway genes influences the risk of developing AMD. Complement factor H gene, an inhibitor of the alternative complement activation pathway along with other complement pathway genes factor F (BF) and C2 show significant contribution to the risk of AMD. The alternative complement pathway is activated by a trigger, which is often microbial in nature. One current model of AMD aetiology implicates aberrant regulation of the alternative pathway of complement, in combination with some unknown infectious agents. <jats:italic>Chlamydia pneumoniae<\/jats:italic> could be one such potential trigger of the alternative complement pathway and several investigations have linked <jats:italic>C.\u2003pneumoniae<\/jats:italic> to AMD<jats:italic>.<\/jats:italic> However, there are only a few studies to date and numbers in most studies are small. Also there are many difficulties in verifying laboratory techniques for the detection of <jats:italic>C.\u2003pneumoniae<\/jats:italic> chronic infection. As such we need to be cautious not to over interpret the current results. However, the findings certainly give impetus for further work on <jats:italic>C.\u2003pneumoniae<\/jats:italic> and AMD. This paper provides an overview of work in this area.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2006.01392.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T10:42:35Z","timestamp":1170844955000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Chlamydia pneumoniae<\/i> and age\u2010related macular degeneration: a role in pathogenesis or merely a chance association?"],"prefix":"10.1111","volume":"35","author":[{"given":"Robyn","family":"Guymer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luba","family":"Robman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0457"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1076\/opep.10.4.215.15906"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.477"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31871-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31034-2"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30846-9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00025-1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00175-5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701978"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02150948"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(00)00025-2"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.3.477"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.835"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1999.0798"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1094"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00961-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00010-6"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222551899"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.6.704"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.07.004"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.6.774"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.5.674"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.01.051"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.067397"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1501"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110359"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110189"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109557"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501536102"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1750"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90001-A"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61257-4"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.03.012"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075693"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/35023175"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.3.301"},{"key":"e_1_2_7_38_2","first-page":"49","article-title":"Emerging relations between infectious diseases and coronary artery disease and atherosclerosis","volume":"163","author":"Fong IW","year":"2000","journal-title":"CMAJ Can Med Assoc Journal"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00168-2"},{"key":"e_1_2_7_40_2","doi-asserted-by":"crossref","unstructured":"StreblowDN OrloffSL NelsonJA.Do pathogens accelerate atherosclerosis?J Nutr2001 131.","DOI":"10.1093\/jn\/131.10.2798S"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.3.218"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/315614"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.4.841"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.4.300"},{"key":"e_1_2_7_45_2","first-page":"33","article-title":"Antibiotic trials for coronary heart disease","volume":"31","author":"Anderson JL","year":"2004","journal-title":"Texas Heart Inst J"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043526"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043528"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1459"},{"key":"e_1_2_7_49_2","unstructured":"GraystonJ.Clinical trials of antibiotic treatment of atherosclerotic disease. In:CherneskyMet\u2003al. eds.Eleventh International Symposium on Human Chlamydial Infection. 2006 June 18\u201323 Niagara\u2010on\u2010the\u2010Lake Ontario Canada pp. 621\u201330."},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.4.478"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.523"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/09286580490514469"},{"key":"e_1_2_7_53_2","first-page":"1","article-title":"Characteristics of progression of early age\u2010related macular degeneration: the cardiovascular health and age\u2010related maculopathy study","volume":"26","author":"Tikellis G","year":"2006","journal-title":"Eye"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi130"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1169-y"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.757"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.451"},{"key":"e_1_2_7_58_2","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1128\/JCM.36.8.2301-2307.1998","article-title":"Evaluation of PCR, culture, and serology for diagnosis of Chlamydia pneumonia Respiratory Infections","volume":"36","author":"Verkooyen R","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-4453(93)94013-2"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309008544"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.3.232"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70287-5"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2005.03.002"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.12.5835-5841.2005"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1086\/466533"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.1.3.493"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1442-9071.2006.01392.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1442-9071.2006.01392.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:13:46Z","timestamp":1696918426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1442-9071.2006.01392.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1442-9071.2006.01392.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1442-9071.2006.01392.x","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}