{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:12Z","timestamp":1790834172923,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T00:00:00Z","timestamp":1300233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>A<jats:sc>bstract<\/jats:sc><\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> To describe the outcome of surgery using amniotic membrane transplantation for Mooren's ulcer.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> A prospective interventional case series from the Vietnam National Institute of Ophthalmology.<\/jats:p><jats:p><jats:bold>Participants:\u2002<\/jats:bold> Eighteen eyes of 14 patients with Mooren's ulcer. Seven eyes had recurrent episodes of ulceration, and 11 were not responsive to medical therapy or conjunctival resection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> All eyes were treated with amniotic membrane grafts for Mooren's ulcer (10 eyes with multilayer grafts; 8 with a single layer graft). Five eyes with a 360\u00b0 peripheral ulcer were treated with an overlay amniotic membrane graft, and 13 eyes were treated with a freehand graft tailored to fit the localized defect.<\/jats:p><jats:p><jats:bold>Main Outcome Measures:\u2002<\/jats:bold> Time to epithelial healing. Visual acuity outcome.<\/jats:p><jats:p><jats:bold>Result:\u2002<\/jats:bold> Sixteen of 18 eyes were treated by a single surgery with amniotic membrane with rapid healing of the epithelial defect (mean time to complete epithelialization 12.4\u2003days). Two eyes required a second amniotic membrane graft: one eye required regrafting following a subgraft haemorrhage and another eye required regrafting for a persistent epithelial defect. Vision was stabilized in all eyes with 10 of 18 eyes obtaining vision of 6\/12 or better.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Amniotic membrane transplantation may be a useful treatment for selected patients with Mooren's ulcer especially where systemic immunosuppressive drugs are unavailable.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2010.02479.x","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T19:15:00Z","timestamp":1293045300000},"page":"386-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Amniotic membrane transplantation for Mooren's ulcer"],"prefix":"10.1111","volume":"39","author":[{"given":"Nguyen D","family":"Ngan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang TM","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199603610-00003"},{"key":"e_1_2_6_3_2","first-page":"1541","article-title":"Autoimmunity to a cornea\u2010associated stromal antigen in patients with Mooren's ulcer","volume":"36","author":"Gottsch JD","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000214216.75496.7e"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.014"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(87)90102-0"},{"key":"e_1_2_6_7_2","first-page":"328","volume-title":"Corneal Surgery: Theory, Technique, and Tissue","author":"Frangieh T","year":"1993"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)33845-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.71.6.415"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199311000-00004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000308904"},{"key":"e_1_2_6_12_2","first-page":"257","article-title":"Mooren's ulcer treated by lamellar keratoplasty","volume":"23","author":"Du NZ","year":"1979","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_13_2","first-page":"564","article-title":"Treatment of Mooren's and Mooren's\u2010like ulcer by lamellar keratectomy: report of six eyes and literature review","volume":"18","author":"Martin N","year":"1987","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_6_14_2","unstructured":"KinoshitaS KoizumiN SotozonoC InatomiB YokoiN.The long term outcome of keratoepithelioplasty in Mooren's ulcer. Program and abstracts of the Cornea Society and Eye Bank Association of America at the American Academy of Ophthalmology and European Society of Ophthalmology 2004 Joint Meeting; October 23\u201326 2004; New Orleans Louisiana."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(80)90120-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.11.1244"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199509000-00006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2003.10.004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000151501.80952.c5"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00825-4"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)01032-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.024"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30841-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(84)90179-X"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.67.7.475"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200105000-00015"},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.4049\/jimmunol.154.11.5665","article-title":"The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA\u2010E and HLA\u2010G","volume":"154","author":"Houlihan JM","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00208.x"},{"key":"e_1_2_6_29_2","first-page":"1539","article-title":"Immunogenicity of human amniotic membrane in experimental xenotransplantation","volume":"42","author":"Kubo M","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5239.1189"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(99)00034-0"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1442-9071.2010.02479.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1442-9071.2010.02479.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1442-9071.2010.02479.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T14:08:49Z","timestamp":1697378929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1442-9071.2010.02479.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,16]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1442-9071.2010.02479.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1442-9071.2010.02479.x","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,16]]},"assertion":[{"value":"2011-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}