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This article outlines the current evidence for the nature of this relationship and highlights the current mathematical models linking structure and function. Large clinical trials demonstrate that both structural and functional change are apparent in advanced stages of disease, and at an individual level, detectable structural abnormality may precede functional abnormality in some patients, whereas the converse is true in other patients. Although the exact nature of the \u2018structure\u2013function\u2019 relationship in primary open\u2010angle glaucoma is still the topic of scientific debate and the subject of continuing research, this article aims to provide the clinician with an understanding of the past concepts and contemporary thinking in relation to the structure\u2013function relationship in primary open\u2010angle glaucoma.<\/jats:p>","DOI":"10.1111\/j.1442-9071.2012.02770.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T10:08:28Z","timestamp":1329473308000},"page":"369-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["\u2018Structure\u2013function relationship\u2019 in glaucoma: past thinking and current 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