{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:04:40Z","timestamp":1793639080401,"version":"4.5.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aromatase inhibitors are frequently used as an adjuvant therapy in the treatment of breast cancer. We observed that several patients taking aromatase inhibitors presented with severe dry eye symptoms, and we investigated whether there is a relationship between aromatase inhibitors and dry eyes in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Forty\u2010one women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A computerized search of health records was performed to identify patients using anastrazole, letrozole and exemestane seen by the Cornea Service from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2008 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2011. The results were compared with age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Ocular surface changes among aromatase inhibitors users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 41 women, 39 were Caucasians. Thirty\u2010nine patients had breast cancer (95%), one patient had ovarian cancer (2.5%) and one had an unknown primary cancer. Mean age was 68\u2009\u00b1\u200911.3 years (range 47\u201395). Most common presenting symptoms were blurred vision in 28 (68%) patients, irritation\/foreign body sensation in 12 (29%) patients, redness in 9 (22%) patients, tearing in 6 (22%) patients and photosensitivity in 2 (5%) patients. Mean Schirmer's test measurement was 11\u2009\u00b1\u20095.8\u2009mm (range 0.5\u201320\u2009mm). Blepharitis was noted in 68 of 82 eyes (73%), decreased or poor tear function in 24 eyes (29%), conjunctival injection in 18 eyes (22%) and superficial punctate keratitis in 12 eyes (29%). Among an age\u2010matched population (45\u201395 years), dry eye syndrome was found in only 9.5% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because the prevalence of ocular surface disease signs and symptoms appears to be higher in study group than control patients, aromatase inhibitors might be a contributing factor to the dry eye symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1442-9071.2012.02865.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T13:29:10Z","timestamp":1347024550000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Dry eye syndrome in aromatase inhibitor users"],"prefix":"10.1111","volume":"41","author":[{"given":"Kiran","family":"Turaka","sequence":"first","affiliation":[{"name":"Cornea Service, Wills Eye Institute Thomas Jefferson University  Philadelphia Pennsylvania 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