{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:34:44Z","timestamp":1694464484913},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Background and aim<\/jats:title>Little is known about the clinical significance of treatment for endoscopically determined peptic ulcers (EPU<\/jats:styled-content>), incidentally detected as surrogate endpoints for non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs<\/jats:styled-content>)\u2010associated ulcers complication, such as overt bleeding and perforation. Even uncomplicated\u2010EPU<\/jats:styled-content> without overt bleeding signs when antithrombotic agents (AT<\/jats:styled-content>) were cotherapied may be of potential bleeding sites. The aim of the present study was to evaluate whether microcytic anemia, implying potential bleeding, is associated with NSAIDs<\/jats:styled-content>\u2010associated EPU<\/jats:styled-content> or cotherapies with AT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Two hundred and thirty\u2010eight outpatients with rheumatoid arthritis under long\u2010term NSAIDs<\/jats:styled-content> therapies underwent upper endoscopy and were divided into the following four groups according to the pattern (presence: + or absence: \u2013) of AT<\/jats:styled-content> cotherapy\/EPU<\/jats:styled-content>, respectively: A, \u2013\/\u2013 (n<\/jats:italic>\u2009=\u2009165); B, \u2013\/+ (n<\/jats:italic>\u2009=\u200944); C, +\/\u2013 (n<\/jats:italic>\u2009=\u200925); and D, +\/+ (n<\/jats:italic>\u2009=\u20094).<\/jats:p><\/jats:sec>Results<\/jats:title>EPU<\/jats:styled-content> were found in 48 of the 238 studied patients (20.2%). After significant interactions among four groups hadstatistically been identified, hemoglobin (Hb<\/jats:styled-content>) and mean corpuscular volume (MCV<\/jats:styled-content>) as biomarkers for potential bleeding were compared between the groups.Hb and MCV<\/jats:styled-content> were significantly lower in the D group than in the A,B, or C groups (Hb: P<\/jats:italic>\u2009<\u20090.01, respectively; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05, MCV<\/jats:styled-content>; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.01 or P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with NSAIDs<\/jats:styled-content>\u2010associated EPU<\/jats:styled-content> and AT<\/jats:styled-content> cotherapy indicated significantly more severe microcytic anemia pattern than those without EPU<\/jats:styled-content> or AT<\/jats:styled-content> cotherapy, despite no evidence of overt bleeding. Even uncomplicated\u2010EPU<\/jats:styled-content> without overt bleeding when ATs<\/jats:styled-content> were cotherapied may be of potential bleeding sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1443-1661.2012.01334.x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T02:29:16Z","timestamp":1339468156000},"page":"25-31","source":"Crossref","is-referenced-by-count":3,"title":["Implication of antithrombotic agents on potential bleeding from endoscopically determined peptic ulcers, incidentally detected as surrogate markers for nsaids\u2010associated ulcers complication"],"prefix":"10.1111","volume":"25","author":[{"given":"Kazumasa","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagoya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kodaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Gudis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Tsukui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Joint Disease and Rheumatism Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012061-00004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04038.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X162656"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080754"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-8-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.18.1714"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52502.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.19.2214"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4308"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52208.x"},{"key":"e_1_2_6_12_1","first-page":"357","article-title":"Women's Health and Aging Studies. 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