{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:45:57Z","timestamp":1784666757488,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Radiation proctitis, a common condition associated with radiotherapy for the treatment of pelvic cancers, is characterized by difficult to manage rectal pain and bleeding. Cryotherapy is a novel technique, previously used in the treatment of vascular ectasias in the upper gastrointestinal tract. The aim of the present study was to determine the efficacy of cryospray application in the treatment of radiation proctitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective case\u2010series pilot study. Ten patients with symptomatic chronic radiation proctitis were consecutively enrolled over a 2\u2010year period. Baseline clinical data were collected and an endoscopic score was calculated based on the density of ectasias and circumferential involvement. Subjects underwent up to four cryospray ablation treatment sessions at approximately 4\u2010week intervals or until resolution of the proctitis. The endpoints of the study were endoscopic and clinical improvement in radiation proctitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients (nine males and one female) with a mean age of 74\u2009\u00b1\u20097 years underwent cryospray treatment; sessions ranged from one to four (six patients had one session, three patients had two sessions, and one patient underwent four sessions). Endoscopic score significantly decreased from a mean of 10.2\u2009\u00b1\u20093.0 to 4.0\u2009\u00b1\u20092.8 (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.016). Rectal pain significantly decreased from a mean of 3.1\u2009\u00b1\u20093.0 to 1.2\u2009\u00b1\u20091.7 (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.042) and rectal bleeding improved in 86% (six out of seven) of patients. Nine patients reported improvement in overall well\u2010being. No major complications were encountered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cryotherapy is an effective method in the management of chronic radiation proctitis with minimal complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1443-1661.2012.01355.x","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T19:33:42Z","timestamp":1343417622000},"page":"174-179","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of cryospray ablation for the treatment of chronic radiation proctitis in a pilot study"],"prefix":"10.1111","volume":"25","author":[{"given":"Fouad J.","family":"Moawad","sequence":"first","affiliation":[{"name":"Gastroenterology Service, Department of Medicine Walter Reed National Military Medical Center"},{"name":"Uniformed Services University of the Health Sciences  Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne L.","family":"Maydonovitch","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Department of Medicine Walter Reed National Military Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J David","family":"Horwhat","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Department of Medicine Walter Reed National Military Medical Center"},{"name":"Uniformed Services University of the Health Sciences  Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"315","article-title":"Radiation proctitis: a decade's experience","volume":"51","author":"Wong MT","year":"2010","journal-title":"Singapore Med. 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