{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:47:21Z","timestamp":1776887241432,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of wire\u2010guided biliary cannulation (<jats:styled-content style=\"fixed-case\">WGC<\/jats:styled-content>) on the prevention of post\u2010endoscopic retrograde cholangiopancreatography (<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>) pancreatitis (<jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the impact of the <jats:styled-content style=\"fixed-case\">WGC<\/jats:styled-content> technique on the incidence of <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> by comparing the conventional cannulation (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) technique in selective bile duct cannulation during <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> with a cross\u2010over design in a prospective multicenter randomized controlled trial and the potential risk factors for <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content>. This involved six tertiary referral centers and three university hospitals. A total of 322 patients with indications for <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> requiring selective biliary cannulation were enrolled from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2008 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010three patients were assigned to the <jats:styled-content style=\"fixed-case\">WGC<\/jats:styled-content> group and 159 to the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> group. The incidence of <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> was the same between the groups (6.1% <jats:italic>vs<\/jats:italic> 6.3%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.95). Primary successful biliary cannulation was achieved in 136 patients (83%) in the <jats:styled-content style=\"fixed-case\">WGC<\/jats:styled-content> group and in 138 (87%) in the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> group (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.40). The mean time required for primary successful biliary cannulation was 7.4\u2009\u00b1\u20098.3\u2009min and 7.2\u2009\u00b1\u20097.9\u2009min, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.83). Multivariate analysis demonstrated that accidental guidewire insertions and unintended injections of contrast into the main pancreatic duct were the only independent risk factors for <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001, relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>]: 8.70, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 2.46\u201330.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">WGC<\/jats:styled-content> technique does not reduce the risk of <jats:styled-content style=\"fixed-case\">PEP<\/jats:styled-content> and also does not improve the success rate of selective bile duct cannulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1443-1661.2012.01372.x","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T09:41:57Z","timestamp":1348047717000},"page":"295-302","source":"Crossref","is-referenced-by-count":41,"title":["Wire\u2010guided biliary cannulation technique does not reduce the risk of post\u2010<scp>ERCP<\/scp> pancreatitis: Multicenter randomized controlled trial"],"prefix":"10.1111","volume":"25","author":[{"given":"Go","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Tohoku Bilio\u2010pancreatic Interventional Endoscopy Group  Tohoku"},{"name":"Department of Gastroenterology Sendai City Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Tohoku Bilio\u2010pancreatic Interventional Endoscopy Group  Tohoku"},{"name":"Department of Gastroenterology Sendai City Medical 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