{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:50:00Z","timestamp":1771462200835,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There is a paucity of data on the cell block (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>) method for bile cytology. We compared the diagnostic efficacy of the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> method with that of conventional smear cytology for bile obtained by endoscopic retrograde cholangiopancreatography (<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>) in a randomized controlled trial manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 137 patients with biliary tract lesions suspicious of malignancy who had undergone bile collection under <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> were recruited to this study. After sampling, the bile was randomized to the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> method (<jats:italic>n<\/jats:italic>\u2009=\u200969) or to smear cytology (<jats:italic>n<\/jats:italic>\u2009=\u200968). <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> sections were prepared using the sodium alginate method and subjected to hematoxylin\u2010eosin, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lcian blue\u2013periodic acid\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chiff stain, and immunohistochemical stains. Both <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>apanicolaou and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>iemsa stains were used for smear cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final diagnosis was malignancy in 94 patients: bile duct cancer, 42; pancreatic head cancer, 34; gallbladder cancer, 16; and ampullary cancer, two. The diagnostic accuracy of the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> method and that of smear cytology were 64% and 53%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.20). The sensitivity of the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> method (53%) was significantly better than that of smear cytology (28%; <jats:italic>P<\/jats:italic>\u2009=\u20090.014). Their respective sensitivities were 80% and 31% (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) for bile duct cancer, 20% and 15% (<jats:italic>P<\/jats:italic>\u2009=\u20091.0) for pancreatic head cancer, and 30% and 67% (<jats:italic>P<\/jats:italic>\u2009=\u20090.30) for gallbladder cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> method for bile cytology showed a higher diagnostic yield than smear cytology. Its diagnostic sensitivity was satisfactory in cases of bile duct cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1443-1661.2012.01404.x","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T10:32:18Z","timestamp":1354789938000},"page":"444-452","source":"Crossref","is-referenced-by-count":14,"title":["Prospective randomized controlled study comparing cell block method and conventional smear method for bile cytology"],"prefix":"10.1111","volume":"25","author":[{"given":"Yutaka","family":"Noda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Horaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Koshita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Masu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Surgery Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Surgery Sendai City Medical Center  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sawai","sequence":"additional","affiliation":[{"name":"First Department of Pathology Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Uzuki","sequence":"additional","affiliation":[{"name":"First Department of Pathology Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyoshi","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.137.6.1123"},{"key":"e_1_2_7_3_1","first-page":"577","article-title":"A prospective, controlled analysis of endoscopic cytotechniques for diagnosis of malignant biliary strictures","volume":"86","author":"Foutch PG","year":"1991","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.10.1408"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.12.1675"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(94)70157-1"},{"key":"e_1_2_7_7_1","first-page":"465","article-title":"Endoscopic transpapillary bile duct biopsy without sphincterotomy for diagnosing biliary stricture: A prospective comparative study with bile and brush cytology","volume":"91","author":"Sugiyama M","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.5.671"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02268.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.01.024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.54.41"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05214.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-011-0419-0"},{"key":"e_1_2_7_14_1","first-page":"1635","volume-title":"Koss's Diagnostic Cytology and its Histopathologic Bases","author":"Ronald AD","year":"2005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0217-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2011.01180.x"},{"key":"e_1_2_7_17_1","first-page":"746","article-title":"Bile cytology. Diagnostic role in the management of biliary obstruction","volume":"39","author":"Nilsson B","year":"1995","journal-title":"Acta Cytol."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.44.291"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199710)17:4<239::AID-DC1>3.0.CO;2-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70004-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70294-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1443-1661.2003.00245.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893391"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00979-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.02.056"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2008.00779.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70671-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(98)70248-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70008-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-73"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.6.449"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5858\/2000-124-0387-AOFNDO","article-title":"Analysis of false\u2010negative diagnoses on endoscopic brush cytology of biliary and pancreatic duct strictures","volume":"124","author":"Logrono R","year":"2000","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.345"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30845.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21842"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.08.039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500389099"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01017.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01698.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01543.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0404-z"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03040.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1717-6"},{"key":"e_1_2_7_44_1","first-page":"1570","volume-title":"Koss's Diagnostic Cytology and its Histopathologic Bases","author":"Bales CE","year":"2005"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1443-1661.2012.01404.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1443-1661.2012.01404.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1443-1661.2012.01404.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1443-1661.2012.01404.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1443-1661.2012.01404.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:16:49Z","timestamp":1694013409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1443-1661.2012.01404.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,6]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/j.1443-1661.2012.01404.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1443-1661.2012.01404.x","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,6]]}}}