{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:20:55Z","timestamp":1774794055487,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T00:00:00Z","timestamp":1098748800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chinese Journal of Digestive Diseases"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:\u2003<\/jats:bold> To determine the distribution of the <jats:italic>iceA<\/jats:italic> and <jats:italic>babA<\/jats:italic>2 genotypes of <jats:italic>Helicobacter pylori<\/jats:italic> in patients with various gastroduodenal diseases in Shanghai, and to explore the association between genotype and the clinical outcome of infection.<\/jats:p><jats:p><jats:bold>METHODS:\u2003<\/jats:bold> One hundred and forty\u2010one strains of <jats:italic>H. pylori<\/jats:italic> were isolated from gastric biopsies of 43 patients with chronic gastritis, 47 with duodenal ulcer (DU), 30 with gastric ulcer (GU) and 21 with non\u2010cardia gastric carcinoma. The <jats:italic>iceA<\/jats:italic>, <jats:italic>babA<\/jats:italic>2<jats:italic>, cagA<\/jats:italic> and <jats:italic>vacA<\/jats:italic> genotypes were determined by polymerase chain reaction (PCR).<\/jats:p><jats:p><jats:bold>RESULTS:\u2003<\/jats:bold> The <jats:italic>iceA<\/jats:italic>1, <jats:italic>iceA<\/jats:italic>2 and <jats:italic>babA<\/jats:italic>2 genotypes were detected in 74.5% (105\/141), 15.6% (22\/141) and 63.8% (90\/141), respectively, of the <jats:italic>H. pylori<\/jats:italic> strains studied. Two <jats:italic>H. pylori<\/jats:italic> isolates (1.4%) were positive for both <jats:italic>iceA<\/jats:italic> alleles and 16 (11.3%) were negative for both. The prevalence of <jats:italic>babA<\/jats:italic>2 and its combination with <jats:italic>cagA<\/jats:italic> (<jats:italic>cagA<\/jats:italic><jats:sup>+<\/jats:sup>\/<jats:italic>babA<\/jats:italic>2<jats:sup>+<\/jats:sup>) in DU patients was significantly higher than that in GU patients (74.5%<jats:italic>vs<\/jats:italic> 50.0% for <jats:italic>babA<\/jats:italic>2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028; 70.2%<jats:italic>vs<\/jats:italic> 46.7% for <jats:italic>cagA<\/jats:italic><jats:sup>+<\/jats:sup>\/<jats:italic>babA<\/jats:italic>2<jats:sup>+<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039). There was no significant difference in the prevalence of <jats:italic>babA<\/jats:italic>2 among the other disease groups, and no significant association of the <jats:italic>iceA<\/jats:italic> genotypes with the different clinical diseases (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><jats:p><jats:bold>CONCLUSIONS:\u2003<\/jats:bold> The most predominant genotype of the <jats:italic>H. pylori<\/jats:italic> strains isolated from patients in Shanghai are <jats:italic>iceA<\/jats:italic>1<jats:sup>+<\/jats:sup>\/<jats:italic>babA<\/jats:italic>2<jats:sup>+<\/jats:sup>, and the <jats:italic>babA<\/jats:italic>2 genotype may play a different role in the pathogenesis of DU and GU. An association between <jats:italic>iceA<\/jats:italic> status and clinical outcome of <jats:italic>H. pylori<\/jats:italic> infection could not be confirmed in the present study.<\/jats:p>","DOI":"10.1111\/j.1443-9573.2004.00175.x","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T11:17:50Z","timestamp":1098789470000},"page":"181-185","source":"Crossref","is-referenced-by-count":22,"title":["Clinical relevance of <i>iceA<\/i> and <i>babA<\/i>2 genotypes of <i>Helicobacter pylori<\/i> in a Shanghai population"],"prefix":"10.1111","volume":"5","author":[{"given":"Yue Hua","family":"HAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Zhong","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Yin","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu Dong","family":"XIAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1128\/JCM.37.7.2274-2279.1999","article-title":"Relationship between Helicobacter pylori iceA, cagA and vacA status and clinical outcome: studies in four different countries","volume":"37","author":"Yamaoka Y","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2244-2246.2002"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.21136"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.13.3875-3884.2001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1128\/JCM.38.2.483-488.2000","article-title":"Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in Japan","volume":"38","author":"Ito Y","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.1.18"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.373"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.4.480"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3964-3966.2003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.4.287"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(03)00034-8"},{"key":"e_1_2_5_13_2","first-page":"1903","article-title":"Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation","volume":"61","author":"Prinz C","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.7.2463-2465.2001"}],"container-title":["Chinese Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1443-9573.2004.00175.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1443-9573.2004.00175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:55:10Z","timestamp":1697205310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1443-9573.2004.00175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1111\/j.1443-9573.2004.00175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1443-9573.2004.00175.x","archive":["Portico"],"relation":{},"ISSN":["1443-9611","1443-9573"],"issn-type":[{"value":"1443-9611","type":"print"},{"value":"1443-9573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}