{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:35:57Z","timestamp":1792719357043,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chinese Journal of Digestive Diseases"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:\u2003<\/jats:bold> To assess the histopathological vascular changes after injection of N\u2010butyl\u20102\u2010cyanoacrylate into the vessels of adult rabbits.<\/jats:p><jats:p><jats:bold>METHODS:\u2003<\/jats:bold> The animals used were 42 pure\u2010blood New Zealand white rabbits weighing 2\u20133\u00a0kg. 0.2\u00a0mL cyanoacrylate with lipiodol was injected into the external jugular vein and femoral artery of each rabbit. Tissue specimens were obtained for histopathological study at 3 days, 7 days, 2 weeks, 3 weeks, 4 weeks, 2 months and 3 months after injection.<\/jats:p><jats:p><jats:bold>RESULTS:\u2003<\/jats:bold> The vessels were obliterated immediately after the injection. The main manifestation of histopathology at 3 days to 2 weeks was an acute inflammatory reaction; this progressed to subacute vasculitis at 3 weeks and a chronic granulomatous foreign body reaction developed at 4 weeks. The glue mass essentially disappeared in 2\u20133 months, replaced by fibrotic tissue with partial vascular recanalization. At 3\u00a0weeks after injection, the elastic fibrils of the arterial wall proliferated distinctly, resulting in narrowing of the lumen with subsequent obliteration, whereas the venous wall still showed inflammation and necrosis without hyperplasia of elastic fibrils. Extrusion of glue was observed over 1\u20133 months in both arteries and veins and was obvious in the latter.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:\u2003<\/jats:bold> The histopathological changes after injection of N\u2010butyl\u20102\u2010cyanoacrylate were similar in the arteries and the veins with the exception of hyperplasia of elastic fibrils in the arterial wall and inflammation and necrosis in the venous wall at 2\u20133 weeks. Glue extrusion was seen in both arteries and veins.<\/jats:p>","DOI":"10.1111\/j.1443-9573.2006.00264.x","type":"journal-article","created":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T12:58:06Z","timestamp":1151585886000},"page":"175-179","source":"Crossref","is-referenced-by-count":38,"title":["Histopathological study of vascular changes after intra\u2010arterial and intravenous injection of N\u2010butyl\u20102\u2010cyanoacrylate"],"prefix":"10.1111","volume":"7","author":[{"given":"Yan Mei","family":"WANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu Fang","family":"CHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119501"},{"key":"e_1_2_5_3_2","first-page":"88","article-title":"Endoscopic injection of tissue glue to treat esophagogastric varices","volume":"16","author":"Cheng LF","year":"1999","journal-title":"Chin J Dig Endosc"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05622.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07637.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35312"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814179"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00286-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01564-0"},{"key":"e_1_2_5_10_2","first-page":"95","article-title":"Efficacy and low vascular toxicity of embolization with radical versus anionic polymerization of N\u2010butyl\u20102\u2010cyanoacrylate (NBCA). An experimental study in swine","volume":"30","author":"Levrier O","year":"2003","journal-title":"J Neuroradiol"},{"key":"e_1_2_5_11_2","first-page":"884","article-title":"The mechanism of polymerization of butyl cyanoacrylate in aqueous dispersions","volume":"21","author":"Behan N","year":"2000","journal-title":"Colloid Polymer Sci"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200211000-00013"},{"key":"e_1_2_5_13_2","first-page":"691","article-title":"Europium fluorescence to visualize N\u2010butyl\u20102\u2010cyanoacrylate in embolized vessels of an arteriovenous malformation swine model","volume":"22","author":"Calvo WJ","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_14_2","first-page":"13","article-title":"Combined therapy of cerebral arteriovenous malformations: histological differences between a non\u2010 adhesive liquid embolizing agent and N\u2010butyl\u20102\u2010cyanoacrylate (NBCA)","volume":"21","author":"Duffner F","year":"2002","journal-title":"Clin Neuropathol"}],"container-title":["Chinese Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1443-9573.2006.00264.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1443-9573.2006.00264.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:10:46Z","timestamp":1696907446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1443-9573.2006.00264.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,29]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1443-9573.2006.00264.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1443-9573.2006.00264.x","archive":["Portico"],"relation":{},"ISSN":["1443-9611","1443-9573"],"issn-type":[{"value":"1443-9611","type":"print"},{"value":"1443-9573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,29]]}}}