{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:52:45Z","timestamp":1717944765648},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T00:00:00Z","timestamp":1201651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:\u2003<\/jats:bold> To study the therapeutic value of cryosurgery with combination of <jats:sup>125<\/jats:sup>iodine seed implantation for locally advanced pancreatic cancer.<\/jats:p><jats:p><jats:bold>METHODS:\u2003<\/jats:bold> Thirty\u2010eight patients with locally advanced pancreatic cancer were enrolled in this study. The diagnosis was confirmed by pathology in 31 patients. Ten patients had metastases of the peripancreatic lymph node and eight had liver metastases. The therapy included cryosurgery, which was performed intra\u2010operatively or percutaneously under guidance of ultrasound and\/or computed tomography (CT), and <jats:sup>125<\/jats:sup>iodine seed implantation, which was performed during cryosurgery process or post\u2010cryosurgery under the guidance of ultrasound and\/or CT.<\/jats:p><jats:p><jats:bold>RESULTS:\u2003<\/jats:bold> Eleven patients received intra\u2010operative cryosurgery and 27 received percutaneous cryosurgery. Fourteen patients underwent two procedures of cryosurgery and three underwent three procedures of cryosurgery. <jats:sup>125<\/jats:sup>Iodine seed implantation was performed during the freezing procedure in 29 patients and within 3\u20137\u00a0days after cryosurgery in nine patients under ultrasound and CT guidance. Fifteen patients, of whom 13 had metastases of peripancreatic lymph nodes or liver received regional chemotherapy. At 3\u00a0months after therapy, a CT follow\u2010up was performed to estimate the tumor response to therapy. Most of the patients had varying degrees of tumor necrosis. A complete response of the tumor was seen in 23.6% of patients, a partial response in 42.1%, stable disease in 26.3% and progressive disease in 7.9%. The adverse effects associated with cryosurgery mainly included pain of the upper abdomen and increased serum amylase activity. Acute pancreatitis was seen in five patients, one of whom presented a severe type of pancreatitis. During the followed\u2010up of a median of 16\u00a0months (range of 5\u201337) median overall survival was 12\u00a0months, 19 patients (50.0%) survived for 12\u00a0months or longer and four survived for 24\u00a0months or longer.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2003<\/jats:bold> As it is far less invasive than conventional pancreas resection and entails a low rate of adverse effects, cryosurgery should be the choice modality for most patients with locally advanced pancreatic cancer. <jats:sup>125<\/jats:sup>Iodine seed implantation can destroy residue survival cancer cells after cryosurgery. Hence, combination of both modalities has a complementary effect.<\/jats:p>","DOI":"10.1111\/j.1443-9573.2007.00322.x","type":"journal-article","created":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T07:08:54Z","timestamp":1201763334000},"page":"32-40","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cryosurgery with combination of <sup>125<\/sup>iodine seed implantation for the treatment of locally advanced pancreatic cancer"],"prefix":"10.1111","volume":"9","author":[{"given":"Ke Cheng","family":"XU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Zhi","family":"NIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Ze","family":"HU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei 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