{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:23Z","timestamp":1760029103143},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T00:00:00Z","timestamp":1092614400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>  \u2003The aim of the present study was to investigate the effect of <jats:italic>N\u2010<\/jats:italic>acetylcysteine on intestinal reperfusion injury.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>  \u2003Forty Spraque\u2013Dawley rats were divided into four groups (<jats:italic>n<\/jats:italic>\u2003=\u200310): sham, sham\u2003+\u2003<jats:italic>N\u2010<\/jats:italic>acetylcysteine, reperfusion, and reperfusion\u2003+\u2003<jats:italic>N\u2010<\/jats:italic>acetylcysteine. Thirty\u2003minutes of ischaemia\u2003\u00b1\u200330\u2003min of reperfusion was performed under 100\u2003mg\/kg <jats:italic>N\u2010<\/jats:italic>acetylcysteine or placebo, administered 30\u2003min before the operation in the groups where appropriate. Ileum samples were resected for histopathologic evaluation and tissue malondialdehyde and super oxide dismutase level determination.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>  \u2003The mean mucosal injury score and malondialdehyde level of the reperfusion and reperfusion\u2003+\u2003<jats:italic>N\u2010<\/jats:italic>acetylcysteine groups were significantly higher than that of the control and control\u2003+\u2003<jats:italic>N\u2010<\/jats:italic>acetylcysteine group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05, respectively). Mean super oxide dismutase level of the control\u2003+\u2003<jats:italic>N\u2010<\/jats:italic>acetylcysteine group was significantly higher than that of the other groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>  \u2003\n          <jats:italic>N<\/jats:italic>\u2010Acetylcysteine did not prevent intestinal reperfusion injury by means of histopathologic findings and malondialdehyde level.<\/jats:p>","DOI":"10.1111\/j.1445-1433.2004.03111.x","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T13:29:13Z","timestamp":1092662953000},"page":"676-678","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>N<\/i>\u2010Acetylcysteine in intestinal reperfusion injury: an experimental study in rats"],"prefix":"10.1111","volume":"74","author":[{"given":"Selcuk M.","family":"Hazinedaroglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda","family":"Dulger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin A.","family":"Kayaoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mevlut","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Serinsoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan","family":"Canbolat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nezih","family":"Erverdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70550-8"},{"key":"e_1_2_6_3_2","first-page":"47","article-title":"Ischemia\u2010reperfusion injury: role of oxygen\u2010derived free radicals","volume":"548","author":"Granger DN","year":"1986","journal-title":"Acta Physiol. 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