{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:55:38Z","timestamp":1781247338357,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> \u2003The purpose of the present paper was to assess the efficacy of saline, sodium chromoglycate, dexamethasone and aprotinin, in single or in combined use in reducing postoperative pelvic adhesion formation in a rabbit model.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> \u2003A standard lesion was performed to induce adhesion formation. Forty\u2010five rabbits were divided into nine study groups. Group 1 was the non\u2010treatment group. In group 2, 3\u2003cm<jats:sup>3<\/jats:sup> of the rabbits\u2019 own serum was instilled i.p. In group 3, 5\u2003mg\/kg sodium chromoglycate and 3\u2003cm<jats:sup>3<\/jats:sup> of the rabbits\u2019 own serum were administered i.p. The group 4 rabbits were instilled with 5\u2003mg\/kg sodium chromoglycate, 3\u2003cm<jats:sup>3<\/jats:sup> rabbits\u2019 own serum and 1\u2003mg\/kg dexamethasone i.p. The group 5 rabbits were injected with 5000\u2003units aprotinin i.m. 2\u2003h before operation and 5\u2003mg\/kg sodium chromoglycate, 3\u2003cm<jats:sup>3<\/jats:sup> of rabbit serum, 1\u2003mg dexamethasone and 5000\u2003units aprotinin instilled i.p. In group 6, 3\u2003cm<jats:sup>3<\/jats:sup> saline was instilled i.p. Groups 7, 8 and 9 were a repeat of groups 4, 5 and 6 with the exception of replacement of the rabbit serum by 3\u2003cm<jats:sup>3<\/jats:sup> saline. Animals were evaluated for adhesions 10\u2003days after operation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> \u2003Macroscopic adhesion scores of all the groups (2\u22129) were significantly less than scores of the control group (group 1). The macroscopic adhesion scores of group 9 and group 8 were significantly less compared to that of group 7.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> \u2003Intraperitoneal instillation of saline and sodium chromoglycate decreased pelvic adhesion formation significantly in a rabbit model. Addition of aprotinin and dexamethasone to these agents gave a further advantage in decreasing pelvic adhesion formation.<\/jats:p>","DOI":"10.1111\/j.1445-1433.2004.03261.x","type":"journal-article","created":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T15:10:24Z","timestamp":1101913824000},"page":"1111-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Prevention of adhesions by sodium chromoglycate, dexamethasone, saline and aprotinin after pelvic surgery"],"prefix":"10.1111","volume":"74","author":[{"given":"Tuncay","family":"Kucukozkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayezit","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Uygur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemal","family":"Gundogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"617","article-title":"The gynecologic contribution to intestinal obstruction in females","volume":"178","author":"Stricler B","year":"1994","journal-title":"J. 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