{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:58:37Z","timestamp":1758815917932},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T00:00:00Z","timestamp":1200873600000},"content-version":"vor","delay-in-days":6928,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Australian and New Zealand Journal of Surgery"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:p>Three hundred and eighty\u2010one patients who underwent major neurosurgical procedures were given cimetidine prophylaxis against stress ulceration. Nine patients (2.4%) developed acute gastrointestinal complications; two patients had perforation and bleeding from gastroduodenal ulcers, and seven patients had bleeding alone. Six of these patients, all above the age of 70 years, died as a consequence of the complication. Univariate analysis showed that four variables\u2014state of consciousness, syndrome of inappropriate secretion of antidiuretic hormone, nature of surgery, and age\u2014were significant factors in predicting cimetidine failure. Multivariate analysis revealed that a patient's pre\u2010operative state of consciousness and the presence of inappropriate secretion of antidiuretic hormone were of independent significance in predicting cimetidine failure. The risk was 52% and 0.07%. Respectively, when both factors were either present or absent.<\/jats:p>","DOI":"10.1111\/j.1445-2197.1989.tb01483.x","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T11:09:52Z","timestamp":1200913792000},"page":"133-136","source":"Crossref","is-referenced-by-count":7,"title":["FAILURE OF CIMETIDINE PROPHYLAXIS IN NEUROSURGERY"],"prefix":"10.1111","volume":"59","author":[{"given":"Kwan\u2010Hon","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KirpalS.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Peptic ulcers and the interbrain.","volume":"55","author":"Cushing H.","year":"1938","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658279"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307073090105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90228-7"},{"key":"e_1_2_1_6_2","first-page":"122","volume-title":"proceedings of symposium pirenzepine\u2014new aspects in research and therapy","author":"Klein H. J.","year":"1984"},{"key":"e_1_2_1_7_2","volume-title":"bmdp statistical software","author":"Dixon W. J.","year":"1983"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1227\/00006123-198706000-00025","article-title":"Severe thrombocytopenia due to combined cimetidine and phenytoin therapy.","volume":"20","author":"Yue C. P.","year":"1987","journal-title":"Neurosurgery"},{"key":"e_1_2_1_9_2","first-page":"355","volume-title":"statistical methods for survival data analysis","author":"Lee E. T.","year":"1980"},{"key":"e_1_2_1_10_2","first-page":"31","volume-title":"gastroenterology annual","author":"Koelz H. R.","year":"1983"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600407"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.30.2.0107"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1971.34.4.0506"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1961.18.5.0661"},{"key":"e_1_2_1_15_2","first-page":"214","article-title":"The prevention of upper gastrointestinal tract bleeding in patients in an intensive care unit.","volume":"153","author":"Zinner M. J.","year":"1981","journal-title":"Surg. Gynecol. Obstet."}],"container-title":["Australian and New Zealand Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-2197.1989.tb01483.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-2197.1989.tb01483.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:06:16Z","timestamp":1700715976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-2197.1989.tb01483.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1111\/j.1445-2197.1989.tb01483.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-2197.1989.tb01483.x","archive":["Portico"],"relation":{},"ISSN":["0004-8682"],"issn-type":[{"value":"0004-8682","type":"print"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}