{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:39:52Z","timestamp":1761154792620},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> Many surgeons now perform carotid endarterectomy under regional anaesthesia. The aim of the present study was to review a sedation technique using a computer\u2010controlled infusion of propofol.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A consecutive series of 84 carotid endarterectomies done by a single surgeon and commenced under regional anaesthesia with sedation was studied. There were 54 men and 27 women (three bilateral procedures), with a median age of 71\u2003years (range 48\u221287\u2003years). All patients had carotid stenosis &gt;70% 80 procedures were done for symptomatic disease and three asymptomatic patients were treated before cardiac surgery (one bilateral).<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Seventy\u2010seven procedures were completed under regional anaesthesia and sedation alone; seven required conversion to general anaesthetic, usually for intolerance of the operation. An intraoperative shunt was required on only four occasions (5%). Postoperatively eight patients required critical care monitoring, usually for blood pressure control. The remainder were nursed on the vascular ward, and 68% were discharged home on the day after surgery. No patient died, but there were two neurological complications. One patient had a cerebellar stroke 10\u2003days after surgery, but recovered fully after 4\u2003months. A second developed cerebral oedema due to severe intraoperative hypertension and required intensive care for 15\u2003days. He too recovered fully. Five patients had a further episode of transient cerebral ischaemia within 1\u2003month of operation, but in all cases duplex imaging showed a widely patent carotid and there were no sequelae.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Target controlled propofol infusion is an effective method of sedation in patients undergoing carotid endarterectomy.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2005.03434.x","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:12:15Z","timestamp":1119442335000},"page":"546-549","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Regional anaesthesia and propofol sedation for carotid endarterectomy"],"prefix":"10.1111","volume":"75","author":[{"given":"Christopher","family":"Barringer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"McCrirrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonothan J.","family":"Earnshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.6.910"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.95.4.168"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80178-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1382"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70008-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-7339(97)80031-4"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1502"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1996.tb04518.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/73.2.167"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1369"},{"key":"e_1_2_7_12_2","first-page":"446","article-title":"Carotid artery surgery using local anaesthetic","volume":"58","author":"Donato AT","year":"1992","journal-title":"Am. 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