{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:41:13Z","timestamp":1697521273571},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T00:00:00Z","timestamp":1159401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Introduction:\u2003<\/jats:bold> The reported range in rates of aspirin resistance (5.5\u201360%) may reflect difficulties in studying platelet function and the variety of tests used. This study used a platelet function analyzer (PFA\u2010100) to prospectively document aspirin resistance in a cohort of patients with arterial disease.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> Patients with internal carotid artery (ICA) stenosis or intermittent claudication (IC) were recruited. Exclusion criteria were contraindications to aspirin, prescription of other medication with known antiplatelet effects or known platelet abnormalities. After prescription of 100\u2003mg aspirin\/day for 2\u2003weeks an uncuffed venous blood sample was taken and analysed with the PFA\u2010100. Aspirin resistance was defined as closure time (CT) less than the upper limit of normal (158\u2003s collagen\/epinephrine agonist; 118\u2003s collagen\/adenosine diphosphate (ADP) agonist).<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Thirty\u2010three patients with IC and 12 patients with ICA stenosis were recruited (<jats:italic>n<\/jats:italic>\u2003=\u200345). Median (range) age was 74\u2003years (49\u201385) and the male to female ratio was 1.5:1. The median (range) CT was &gt;300 (85 to &gt;300)\u2003s with collagen\/epinephrine and 100 (52 to &gt;300)\u2003s with collagen\/ADP agonist. Twelve patients (27%) in the collagen\/epinephrine group had normal CT despite treatment with 100\u2003mg aspirin, indicating resistance. Of the 33 patients with collagen\/epinephrine CT prolonged by aspirin, 10 patients also had prolonged collagen\/ADP CT, suggesting excessive platelet inhibition.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> A significant proportion of patients taking aspirin do not show laboratory evidence of platelet inhibition and may not be protected from atherothrombotic events. The PFA\u2010100 appears to be a useful tool to screen for both aspirin resistance and excessive aspirin mediated platelet inhibition.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2006.03693.x","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T13:13:02Z","timestamp":1159449182000},"page":"873-877","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["POINT OF CARE TESTING OF ASPIRIN RESISTANCE IN PATIENTS WITH VASCULAR DISEASE"],"prefix":"10.1111","volume":"76","author":[{"given":"Shen","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Appleberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01774.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7140.1303"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.41.5.875"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6526.970"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of randomised trials of antiplatelet therapy\u2013I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients","volume":"308","author":"Antiplatelet Trialists\u2019 Collaboration","year":"1994","journal-title":"Br. 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