{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:11:39Z","timestamp":1770822699483,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T00:00:00Z","timestamp":1151280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> The surgical management of patients with multiple endocrine neoplasia\u20102A (MEN\u20102A) continues to evolve with specific genotype\u2013phenotype correlations allowing for a more tailored approach. In this study, we report the surgical management of one of the largest MEN\u20102A families with a rearranged during transfection (RET) codon 804 mutation.<\/jats:p><jats:p><jats:bold>Method:\u2003<\/jats:bold> This is a cohort study comprising all at\u2010risk kindred within a single known MEN\u20102A family. Prophylactic total thyroidectomy with lymph node dissection was recommended to all mutation carriers aged 5\u2003years and older.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> There were a total of 48 at\u2010risk individuals in the MEN\u20102A kindred, with 22 patients undergoing thyroidectomy after appropriate preoperative evaluation. A total of 9 patients had medullary thyroid cancer including 5 with a normal preoperative calcitonin level. A total of 11 patients had C\u2010cell hyperplasia and 7 showed histological evidence of parathyroid disease. Only the index case had a phaeochromocytoma.<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> Genetic testing for germline mutations in the RET proto\u2010oncogene has allowed precise identification of affected RET carriers and provided the opportunity for prophylactic or \u2018preclinical\u2019 surgery to treat and in fact to prevent medullary thyroid cancer. This concept of prophylactic surgery based on a genetic test is likely to be applied more widely as the tools of molecular biology advance.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2006.03783.x","type":"journal-article","created":{"date-parts":[[2006,6,26]],"date-time":"2006-06-26T14:56:28Z","timestamp":1151333788000},"page":"586-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["NEW ERA: PROPHYLACTIC SURGERY FOR PATIENTS WITH MULTIPLE ENDOCRINE NEOPLASIA\u20102A"],"prefix":"10.1111","volume":"76","author":[{"given":"Jessica E.","family":"Gosnell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Sywak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan B.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian 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