{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:48:45Z","timestamp":1778755725995,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T00:00:00Z","timestamp":1206316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Background:\u2003<\/jats:bold> Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of local disease. We conducted a retrospective analysis of patients with DM treated through the Princess Alexandra Hospital Melanoma Clinic to address the role of radiotherapy in the local control of this tumour.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> A review of a clinical database identified 24 patients between January 1997 and March 2006 with histopathologically confirmed DM who had received surgical excision as initial treatment followed by postoperative radiotherapy. All histopathology reports and radiotherapy treatment plans were reviewed. The primary outcome measure was 3\u2010year in\u2010field relapse\u2010free survival.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> There were 24 patients with 22 having a DM in the head and neck region. The median tumour thickness was 5.2\u2003mm. The histopathological margin was less than 10\u2003mm in 17 (71%) of patients. The 3\u2010year in\u2010field relapse\u2010free survival was 91% (95% confidence interval 68.1\u201397.6%), the 3\u2010year relapse\u2010free survival was 86% (95% confidence interval 63.2\u201395.4%) with a 3\u2010year overall survival of 83% (95% confidence interval 54.9\u201394.3%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> In a selected series of patients with DM with a high risk of local recurrence, adjuvant radiotherapy may have been effective in reducing the rate of local recurrence after surgical resection. A randomized trial is currently being developed to confirm this possible benefit.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2008.04436.x","type":"journal-article","created":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T23:37:09Z","timestamp":1206401829000},"page":"273-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["DESMOPLASTIC MELANOMA: THE ROLE OF RADIOTHERAPY IN IMPROVING LOCAL CONTROL"],"prefix":"10.1111","volume":"78","author":[{"given":"Matthew C.","family":"Foote","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Bayley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Mark","family":"Smithers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:4<914::AID-CNCR2820280415>3.0.CO;2-E"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197908000-00002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02071519"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00819-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10263"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1128::AID-CNCR11>3.0.CO;2-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21311"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91448-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1990.tb07515.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10141"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06462.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90198-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1177\/000313480106701020","article-title":"Desmoplastic melanoma","volume":"67","author":"Payne WG","year":"2001","journal-title":"Am. 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