{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:01:13Z","timestamp":1770969673387,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T00:00:00Z","timestamp":1251676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> This review aims to compare the effectiveness of linezolid to vancomycin for the treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) skin and soft tissue infections (SSTIs) in inpatients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and reference lists were searched in March 2007. We included randomized controlled trials that looked at inpatients treated with linezolid versus vancomycin for the treatment of hospital\u2010acquired MRSA SSTIs. Outcome measures were clinical cure (resolution of symptoms and signs) and microbiological cure (eradication of MRSA on wound culture). The validity of the included trials was assessed. The results were combined in meta\u2010analyses, the robustness of which was tested in sensitivity analyses.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Four trials were included in this review: three for clinical outcomes (174 participants) and three for microbiological outcomes (439 participants). For clinical outcomes there were non\u2010significant trends in favour of linezolid (RR 0.34; 95% CI 0.04, 2.89; <jats:italic>P<\/jats:italic>\u2003=\u20030.32). For microbiological outcomes there was weak evidence of linezolid outperforming vancomycin (RR 0.55; 95% CI 0.30, 1.01; <jats:italic>P<\/jats:italic>\u2003=\u20030.05). Sensitivity analyses did not change the conclusions taken from the main analysis.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> With the current available data no difference could be detected between the two treatments, but a trend towards higher effectiveness of linezolid was observed. More data will be required to determine if linezolid is superior to vancomycin for the treatment of MRSA SSTIs. Further systematic reviews are needed to look at other outcomes (length of hospital stay, safety and tolerability, cost\u2010effectiveness) and at MRSA infections at other sites.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2009.05018.x","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T13:51:21Z","timestamp":1251726681000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Linezolid versus vancomycin for MRSA skin and soft tissue infections (systematic review and meta\u2010analysis)"],"prefix":"10.1111","volume":"79","author":[{"given":"Tristan John","family":"Dodds","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Isobel","family":"Hawke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1997.tb07108.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.4.428"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.880-882.2002"},{"key":"e_1_2_8_5_2","first-page":"S67","article-title":"TSN Database Australia, a new tool to monitor antimicrobial resistance in Australia","volume":"27","author":"Turnidge J","year":"2003","journal-title":"Commun. Dis. Intell."},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2001.tb143562.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1995.tb02239.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00284.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.1.138"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-2-200301210-00015"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2723-2726.2002"},{"key":"e_1_2_8_12_2","unstructured":"DonohooE.MIMS Australia Online.2007. Available from URL:http:\/\/www.mims.com.au[Cited 11 August 2009."},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01344.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)90101-9"},{"key":"e_1_2_8_15_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions 4.2.5","author":"Higgins JPT","year":"2005"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04149-5"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6964.1286"},{"key":"e_1_2_8_18_2","unstructured":"LefebvreCMS.Development of a sensitive search strategy for reports of randomized controlled trials in EMBASE.Fourth International Cochrane Colloquium. Adelaide Australia1996."},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.11.1054"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.011"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2260-2266.2005"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000087020.75886.93"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/340353"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290060030"},{"key":"e_1_2_8_26_2","first-page":"15","article-title":"How important is publication bias? A synthesis of available data","volume":"9","author":"Dickersin K","year":"1997","journal-title":"AIDS Educ. Prev."}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-2197.2009.05018.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-2197.2009.05018.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:22:18Z","timestamp":1697466138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-2197.2009.05018.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,31]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1111\/j.1445-2197.2009.05018.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-2197.2009.05018.x","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,31]]},"assertion":[{"value":"2009-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}