{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:11:59Z","timestamp":1760983919369},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T00:00:00Z","timestamp":1301875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Endovascular abdominal aortic aneurysm repair involves manipulation of the aorta around the renal arteries. Fenestrated grafts involve the direct cannulation, stenting and injecting of contrast into the renal arteries. These procedures may be associated with an acute post\u2010operative creatinine rise.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We retrospectively examined data from all endovascular aortic repairs at our institution from 2005 to 2009, where contrast dosage had been recorded. Renal impairment was defined as a 25% increase in creatinine during the 5\u2010day post\u2010operative period. Univariable analysis was undertaken for a number of likely predictors, including: age, contrast dosage, preoperative creatinine, graft type (fenestrated or standard), diabetes mellitus, hypertension, hypercholesterolaemia, ischaemic heart disease, aspirin therapy, statins therapy, non\u2010steroidal anti\u2010inflammatory drug use, preoperative N\u2010acetyl\u2010cysteine and intravenous pre\u2010hydration. Multivariable analysis was then applied to variables with a univariable <jats:italic>P<\/jats:italic>\u2010value of &lt;0.05.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We identified 106 consecutive cases, with complete data for 102. Twenty per cent of patients developed renal impairment (22\/102). Contrast dose (<jats:italic>P<\/jats:italic>= 0.043) and fenestrated grafts (<jats:italic>P<\/jats:italic>= 0.006) were identified as significant risk factors for post\u2010operative creatinine increase (<jats:italic>P<\/jats:italic>= 0.043). Multivariable analysis demonstrated that fenestrated grafts were a risk factor independent of contrast dosage (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Patients who received a fenestration graft (<jats:italic>P<\/jats:italic> &lt; 0.01) and increased contrast dose (<jats:italic>P<\/jats:italic> &lt; 0.05) were at a significant increased risk of a 25% post\u2010operative creatinine rise. The risk of fenestration grafts persisted when multivariable regression was performed to control for contrast dosage (<jats:italic>P<\/jats:italic> &lt; 0.05). Other variables investigated were not found to be significant in this study.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2011.05699.x","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T01:05:24Z","timestamp":1301965524000},"page":"827-830","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of creatinine rise post\u2010endovascular abdominal aortic aneurysm repair"],"prefix":"10.1111","volume":"81","author":[{"given":"Christopher Earle","family":"Brooks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Denton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2008.04679.x"},{"key":"e_1_2_6_3_2","first-page":"367","article-title":"Relationship of proximal fixation to renal dysfunction in patients undergoing endovascular aneurysm repair","volume":"45","author":"Mehta M","year":"2004","journal-title":"J. Cardiovasc. Surg."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.228"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.11.043"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1583\/1074-6218(1998)005<0318:RCFERO>2.0.CO;2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1583\/1545-1550(2003)010<0397:LRFFEA>2.0.CO;2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.09.025"},{"key":"e_1_2_6_9_2","first-page":"568","article-title":"Fenestrated endovascular repair for juxtarenal aortic pathology","volume":"49","author":"Kristmundsson T","year":"2009","journal-title":"J. Endovasc. Ther."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000058421.01661.c5"},{"key":"e_1_2_6_11_2","first-page":"389","article-title":"Atorvastatin attenuated contrast induced renal function damage","volume":"37","author":"Chen GL","year":"2009","journal-title":"Chin. J. Cardiovasc. Dis."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1583\/06-1833.1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp306"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000107562.68920.92"},{"key":"e_1_2_6_15_2","first-page":"1136","article-title":"Prevention of contrast\u2010induced nephropathy in vascular patients undergoing angiography: a randomised controlled trial of intravenous N\u2010acetylcysteine","volume":"16","author":"Rashid ST","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.09.008"},{"key":"e_1_2_6_17_2","first-page":"73","article-title":"Pathophysiology of contrast\u2010 induced nephropathy","volume":"10","author":"Guastoni C","year":"2006","journal-title":"G. Ital. Cardiol."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl779"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000375"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.024"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1583\/07-2299.1"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-2197.2011.05699.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-2197.2011.05699.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:48:16Z","timestamp":1697456896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-2197.2011.05699.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,4]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1445-2197.2011.05699.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-2197.2011.05699.x","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,4]]},"assertion":[{"value":"2011-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}