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Initially used for the transphenoidal removal of hypophyseal adenomas, the endoscopic transnasal approach gradually evolved into a way of accessing the whole ventral skull base. Improved visualization, avoidance of brain retraction, the ability to access directly tumours with minimal damage to critical neurosurgical structures as well lack of external scars are among its obvious benefits. However, it presents the surgeons with a number of challenges, including the need to deal endoscopically with potential arterial bleeding, complicated reconstruction requirements as well as the need for a true team approach. In this review drawing from our experience as well as published series, we present an overview of current indications, challenges and limitations of the expanded endonasal approaches to the skull base.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2011.05971.x","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T01:52:43Z","timestamp":1326851563000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa"],"prefix":"10.1111","volume":"82","author":[{"given":"Amanda","family":"Oostra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"van Furth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Georgalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(03)00065-2"},{"key":"e_1_2_5_3_2","first-page":"247","volume-title":"Practice of Surgery","author":"Dandy W","year":"1932"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199612000-00030"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900555"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00060-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900002"},{"key":"e_1_2_5_8_2","first-page":"1225","article-title":"Une nouvelle technique endoscopique: explorations endoscopiques intracr\u00e2niennes","volume":"72","author":"Guiot G","year":"1963","journal-title":"Presse Med."},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199202000-00016"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.19.1.4"},{"key":"e_1_2_5_11_2","first-page":"E4","article-title":"Expanded endonasal approach: the rostrocaudal axis. 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