{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:01:38Z","timestamp":1778652098020,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Restoration of bowel continuity after a temporary loop ileostomy following rectal resection often produces impaired bowel function. The purpose of this clinical trial was to assess the efficacy of a probiotic, VSL#3 (VSL Pharmaceuticals Inc., Gaithersburg, MD, USA), in improving bowel function following ileostomy closure.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Between March 2005 and April 2008, a prospective, double\u2010blind, placebo\u2010controlled randomized trial of a probiotic preparation was conducted across four South Australian hospitals. Sixty\u2010three patients who underwent a loop ileostomy reversal were randomized to receive 4\u2010week treatment of either probiotic therapy (<jats:italic>n<\/jats:italic>= 31) or placebo (<jats:italic>n<\/jats:italic>= 32). Bowel symptomology was collected through a patient\u2010completed bowel diary and the Gastrointestinal Quality of Life Index (GIQLI).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Completion rates of the 4\u2010week therapy regime were similar for both groups: 18 active <jats:italic>versus<\/jats:italic> 20 placebos. There was no statistically significant difference in the number of patients who withdrew or had adverse events in the two treatment groups. Reasons for patient withdrawal from the study were similar for both groups. Repeated measures analysis of variance showed no statistically significant difference between the GIQLI scores for the two treatment groups.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The use of the probiotic preparation, VSL#3, did not alter the post\u2010operative bowel function of patients undergoing loop ileostomy reversal.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2012.06082.x","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T02:01:45Z","timestamp":1336615305000},"page":"420-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Clinical trial assessing VSL#3 for the treatment of anterior resection syndrome"],"prefix":"10.1111","volume":"82","author":[{"given":"Jacqueline H.","family":"Stephens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Hewett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2002.00352.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050056"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050042"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054232"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055598"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12489-0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i6.853"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020501202369"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70053-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80164-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.078303"},{"key":"e_1_2_7_13_2","first-page":"106","article-title":"Probiotic therapy of IBD","volume":"2","author":"Katz JA","year":"2001","journal-title":"Inflamm. 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