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However, neither form of anti\u2010reflux therapy produces predictable regression, or prevents cancer development. Patients with Barrett's oesophagus usually undergo endoscopic surveillance, which aims to identify dysplastic changes or cancer at its earliest stage, when treatment outcomes should be better. Alternative endoscopic interventions are now available and are suggested for the treatment of early cancer and prevention of progression of Barrett's oesophagus to cancer. Such treatments could minimize the risks associated with oesophagectomy. The current status of these interventions is reviewed. Various endoscopic interventions have been described, but with long\u2010term outcomes uncertain, they remain somewhat controversial. Radiofrequency ablation of dysplastic Barrett's oesophagus might reduce the risk of cancer progression, although cancer development has been reported after this treatment. Endoscopic mucosal resection (EMR) allows a 1.5\u20132\u2009cm diameter piece of oesophageal mucosa to be removed. This provides better pathology for diagnosis and staging, and if the lesion is confined to the mucosa and fully excised, EMR can be curative. The combination of EMR and radiofrequency ablation has been used for multifocal lesions, but long\u2010term outcomes are unknown. The new endoscopic interventions for Barrett's oesophagus and early oesophageal cancer have the potential to improve clinical outcomes, although evidence that confirms superiority over oesphagectomy is limited. Longer\u2010term outcome data and data from larger cohorts are required to confirm the appropriateness of these procedures.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2012.06151.x","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T04:49:12Z","timestamp":1345438152000},"page":"592-598","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ablation of Barrett's oesophagus: towards improved outcomes for oesophageal cancer?"],"prefix":"10.1111","volume":"82","author":[{"given":"George C.","family":"Mayne","sequence":"first","affiliation":[{"name":"Flinders University Department of Surgery Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Bright","sequence":"additional","affiliation":[{"name":"Flinders University Department of Surgery Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian J.","family":"Hussey","sequence":"additional","affiliation":[{"name":"Flinders University Department of Surgery Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Watson","sequence":"additional","affiliation":[{"name":"Flinders University Department of Surgery Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2010.01054.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00548.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80011-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2009.05107.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540309"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00646.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906013202218"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004103021506"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318133fa85"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i30.3773"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5063"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2006.12.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i30.3780"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1103416"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70004-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.12.023"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23573"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.061"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02277.x"},{"key":"e_1_2_12_22_1","first-page":"A139","article-title":"Photodynamic therapy (PDT) versus argon plasma, coagulation (APC) for ablative therapy of Barrett's esophagus","volume":"57","author":"Zoepf T","year":"2003","journal-title":"Gastrointest. 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