{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:03:57Z","timestamp":1777421037906,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstracts<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low resectability rate and poor survival outcomes after surgical resection for hilar cholangiocarcinoma are common in most institutions. We retrospectively reviewed the surgical outcomes of hilar cholangiocarcinoma in a tertiary institution focusing on the surgical procedures, radicalities, survival rates and independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred thirty patients who underwent surgical resection for hilar cholangiocarcinoma between 1995 and 2010 were retrospectively analysed based on the clinical variables, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ismuth\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>orlette types, radicality of operation and survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median overall and disease\u2010free survival time in the whole cohort were 39.1 and 19.2 months, respectively. Patients with type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> tumour were more likely to undergo segmental bile duct resection than combined liver resection with lower <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>0 rates (68.2% and 76.1%, respectively). Liver resection (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> &lt; 0.001) and combined caudate lobectomy (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.003) were associated with significantly higher <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>0 rates. Multivariate analysis showed that lymph node metastasis (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.001), preoperative level of bilirubin above 3.0\u2009mg\/d<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.003) and positive resection margin (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.033) were independent prognostic factors on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver resection and combined caudate lobectomy increased curative resection rates in hilar cholangiocarcinoma regardless of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ismuth\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>orlette types. Preoperative biliary drainage should be performed in jaundiced patients to improve perioperative outcome and survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-2197.2012.06195.x","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:11:23Z","timestamp":1346717483000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Surgical outcomes of 230 resected hilar cholangiocarcinoma in a single centre"],"prefix":"10.1111","volume":"83","author":[{"given":"Sun Choon","family":"Song","sequence":"first","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred Wei\u2010Chieh","family":"Kow","sequence":"additional","affiliation":[{"name":"Division of HPB Surgery and Liver Transplantation Department of Surgery University Surgical Cluster, National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199610000-00005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i10.1505"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-004-2832-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4240"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-005-0070-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658686"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200110000-00010"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050167"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.10.028"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.07.033"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-009-0209-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181afe0ab"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03595.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000094437.68038.a3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480607200706"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.09.016"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1168-z"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1325-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1957.01280150140015"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90178-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197309000-00013"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40150-7"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198110000-00008"},{"key":"e_1_2_5_25_1","first-page":"614","article-title":"Changing pattern in diagnosis and management of bile duct cancer","volume":"211","author":"Tompkins RK","year":"1990","journal-title":"Ann. 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