{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:27:06Z","timestamp":1726759626859},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent reports have suggested that a certain type of subtrochanteric and diaphyseal femoral fractures maybe associated with bisphosphonate (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) therapy. We assessed the association between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> use in atypical and typical femoral fractures in a retrospective study and also looked at the rate of coding errors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cases between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2003 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2008 with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lassification of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease, 10th revision discharge codes for femoral fractures (S72.2 subtrochanteric and S72.3 fracture of shaft of femur) were reviewed. Cases were excluded if there was significant trauma, underlying bone disease or coding error. The remaining cases\u2019 films were assessed by an independent, blinded, single radiologist to assess for atypical features (thickened cortices, transverse fractures, medial cortical spike) with additional exclusion criteria of periprosthetic fractures and bone pathology. Odds ratios were calculated comparing <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> use in atypical and typical fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six atypical fractures were found in the study period. Compared with the 65 typical fractures, there was an association between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> use and atypical fractures (odds ratio 5.5) but it did not reach statistical significance (0.97\u201331). Atypical femoral fractures accounted for &lt;0.1% of total fracture admissions during this period. There was a 20% rate of miscoding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows a nonsignificant trend towards alendronate\/<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> use and atypical femoral fractures compared with typical femoral fractures. These fractures were rare &lt;0.1% and the benefit and treatment of osteoporosis with <jats:styled-content style=\"fixed-case\">BPs<\/jats:styled-content> currently seems likely to outweigh the perceived risks. Individual case and radiology review is important as coding errors were frequent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-2197.2012.06199.x","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:11:38Z","timestamp":1346717498000},"page":"908-912","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Atypical subtrochanteric fractures, bisphosphonates, blinded radiological review"],"prefix":"10.1111","volume":"82","author":[{"given":"Christopher","family":"Warren","sequence":"first","affiliation":[{"name":"Department of Older Person's Health The Princess Margaret Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Department of Older Person's Health The Princess Margaret Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Coates","sequence":"additional","affiliation":[{"name":"Department of Radiology Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Frampton","sequence":"additional","affiliation":[{"name":"Department of Medicine Christchurch School of Medicine and Health Sciences University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Helmore","sequence":"additional","affiliation":[{"name":"CGM Research Trust The Princess Margaret Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McKie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Hooper","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BrownP McNeillR RadwanE WillingaleJ.The burden of osteoporosis in New Zealand: 2007\u20132020.Centre for Health Services Research and Policy for Osteoporosis New Zealand Inc2007:1\u201352."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2023H"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030897"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1947"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B3.18146"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0707493"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e318172841c"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0952"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001086"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.253"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010650"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.233"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.08.036"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081247"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0910389"},{"key":"e_1_2_6_18_1","unstructured":"DellR GreenD OttSet\u2009al.A retrospective analysis of all atypical femur fractures seen in a large California HMO from years 2007 to 2009.ASBMR Annual Meeting Toronto Canada.2010. 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