{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:50:12Z","timestamp":1763563812318},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T00:00:00Z","timestamp":1346630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acute acalculous cholecystitis (AAC<\/jats:styled-content>) is traditionally described in the setting of critical illness, where the diagnosis is based on clinical assessment and imaging criteria. Very few studies have assessed the features and outcomes of AAC<\/jats:styled-content> in patients treated by cholecystectomy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with histologically confirmed acute cholecystitis treated in a specialized unit in a tertiary hospital between 2005 and 2011 were identified from prospectively maintained database. Retrospective review of data was undertaken and patients with AAC<\/jats:styled-content> were compared with those patients with acute cholecystitis and confirmed gallstones.<\/jats:p><\/jats:sec>Results<\/jats:title>AAC<\/jats:styled-content> was identified in 35 of 412 (8.5%) patients with acute cholecystitis. These patients were older (69 years versus 61 years; P<\/jats:styled-content><\/jats:italic> = 0.004) and were more likely to be febrile (46% versus 21%; P<\/jats:styled-content><\/jats:italic> = 0.001) and hypotensive (23% versus 5%; P<\/jats:styled-content><\/jats:italic> < 0.001) at initial presentation. There was a higher incidence of chronic obstructive airways disease (COAD<\/jats:styled-content>) in the AAC<\/jats:styled-content> group (26% versus 6%; P<\/jats:styled-content><\/jats:italic> < 0.001). Other co\u2010morbidities were similar among the groups. Operative outcomes were similar between the groups. There were no overall differences in postoperative complications between AAC<\/jats:styled-content> and calculous acute cholecystitis patients (17% versus 16%; P<\/jats:styled-content><\/jats:italic> = 0.063). However, the postoperative length of stay was higher in the AAC<\/jats:styled-content> group (5 days versus 3 days; P<\/jats:styled-content><\/jats:italic> = 0.026).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>AAC<\/jats:styled-content> more commonly occurs in older patients and those with COAD<\/jats:styled-content>. The operative outcomes and complications of AAC<\/jats:styled-content> treated by cholecystectomy are similar to cases of acute calculous cholecystitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-2197.2012.06202.x","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:11:43Z","timestamp":1346717503000},"page":"918-922","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcomes of patients with histologically proven acute acalculous cholecystitis"],"prefix":"10.1111","volume":"82","author":[{"given":"Mehrdad","family":"Nikfarjam","sequence":"first","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Manya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Fink","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Hadj","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayaragavan","family":"Muralidharan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Starkey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Christophi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Austin Health University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199004000-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(81)90155-0"},{"key":"e_1_2_6_4_1","first-page":"99","article-title":"Acute acalculous cholecystitis \u2013 a clinical\u2010pathological disease spectrum","volume":"37","author":"Warren BL","year":"1999","journal-title":"S. 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