{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T18:01:07Z","timestamp":1698861667976},"reference-count":25,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium ulcerans<\/jats:italic> causes significant morbidity in various endemic locations in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>est <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frica. The commonest presentation is as a necrotic ulcer often with surrounding subcutaneous necrosis and oedema, which can cause significant morbidity, deformity and functional impairment. Traditional treatment was wide excision and debridement with grafting or flap reconstructions further adding to morbidity and with high recurrence rates. Following publication of clinical studies where antibiotics were shown to be effective, treatment has moved towards combination management with systemic antibiotics and limited surgery involving mainly debridement of the ulcers. Identification of the \u2018paradoxical\u2019 immune\u2010reconstitution syndrome has also impacted upon the extent of excision required. This paper will present the evolution in clinical management of <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u2009ulcerans<\/jats:italic> cases on the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ellarine <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eninsula, <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ictoria, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia.<\/jats:p>","DOI":"10.1111\/j.1445-2197.2012.06230.x","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T04:38:06Z","timestamp":1348029486000},"page":"523-526","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i><scp>M<\/scp>ycobacterium ulcerans<\/i> infection: evolution in clinical management"],"prefix":"10.1111","volume":"83","author":[{"given":"Candice","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Barwon Health  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Barwon Health  Geelong Victoria Australia"},{"name":"Department of Medicine and Infectious Diseases Royal Melbourne Hospital University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Barwon Health  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Callan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Barwon Health  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01156-3"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020108"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000933"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14417-0"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00175-07"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.09.006"},{"key":"e_1_2_4_8_1","first-page":"785","article-title":"Mycobacterium ulcerans disease","volume":"83","author":"Werf TS","year":"2005","journal-title":"Bull. 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