{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:04:35Z","timestamp":1781687075186,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>G<\/jats:styled-content>raves\u2019 disease is a common cause of thyrotoxicosis. Treatment options include anti\u2010thyroid medications or definitive therapy: thyroidectomy or radioactive iodine (I<\/jats:styled-content>131<\/jats:sup>). Traditionally, I<\/jats:styled-content>131<\/jats:sup> has been the preferred definitive treatment for Graves\u2019 disease in N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand. Reports of concomitant thyroid cancer occurring in up to 17% of G<\/jats:styled-content>raves\u2019 patients suggest surgery, if performed with low morbidity, may be the preferred option. The aim of this study was to determine the rate of thyroid cancer and surgical outcomes in a N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand cohort of patients undergoing thyroidectomy for G<\/jats:styled-content>raves\u2019 disease.<\/jats:p><\/jats:sec>Method<\/jats:title>This study is a retrospective review of W<\/jats:styled-content>aikato region patients undergoing thyroid surgery for G<\/jats:styled-content>raves\u2019 disease during the 10\u2010year period prior to 1 D<\/jats:styled-content>ecember 2011.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 833 patients underwent thyroid surgery. Of these, 117 were for G<\/jats:styled-content>raves\u2019 disease. Total thyroidectomy was performed in 82, near\u2010total in 33 and subtotal in 2 patients. Recurrent thyrotoxicosis developed in one subtotal patient requiring I<\/jats:styled-content>131<\/jats:sup> therapy. There were two cases of permanent hypoparathyroidism and one of permanent recurrent laryngeal nerve palsy. Eight patients (6.8%) had thyroid cancer detected, none of whom had overt nodal disease. Five were papillary microcarcinomas (one of which was multifocal), two were papillary carcinomas (11\u2009mm and 15\u2009mm) and one was a minimally invasive follicular carcinoma.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Thyroid cancer was identified in approximately 7% of patients undergoing surgery for G<\/jats:styled-content>raves\u2019 disease. A low complication rate (<2%) of permanent hypoparathyroidism and nerve injury (<1%) supports surgery being a safe alternative to I<\/jats:styled-content>131<\/jats:sup> especially for patients with young children, ophthalmopathy or compressive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-2197.2012.06233.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T02:02:03Z","timestamp":1347933723000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Thyroid cancer in G<\/scp>raves\u2019 disease: is surgery the best treatment for G<\/scp>raves\u2019 disease?"],"prefix":"10.1111","volume":"84","author":[{"given":"Jade A. U.","family":"Tamatea","sequence":"first","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelson","family":"Tu'akoi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Auckland Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Conaglen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Faculty of Medicine University of Auckland Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne S.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Waikato Hospital Hamilton New Zealand"},{"name":"Faculty of Medicine University of Auckland Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goswin Y.","family":"Meyer\u2010Rochow","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Auckland Hamilton New Zealand"},{"name":"Department of Surgery Waikato Hospital Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00554.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.022"},{"key":"e_1_2_7_4_1","first-page":"325","article-title":"Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter","volume":"94","author":"Karagulle E","year":"2009","journal-title":"Int. Surg."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-010-9405-6"},{"key":"e_1_2_7_7_1","first-page":"115","article-title":"Outcome of incidental thyroid carcinoma in patients undergoing surgery for Graves\u2019 disease","volume":"112","author":"D\u0103nil\u0103 R","year":"2008","journal-title":"Rev. Med. Chir. Soc. Med. Nat. Iasi"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.12.006"},{"key":"e_1_2_7_9_1","first-page":"244","article-title":"Thyroid nodules in Graves\u2019 disease: implications in an endemically iodine deficient area","volume":"47","author":"Mishra A","year":"2001","journal-title":"J. Postgrad. Med."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01504.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9219-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1513"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1283"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0337-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2002.02400.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2329"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.17.3.456"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0450"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0392"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26070"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22635"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3413\/Nukmed-0341-10-08"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199809000-00005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2009.04894.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106003501"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03897.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0886-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7219"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9545-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32834473dc"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.152"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.08.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318230036d"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299741"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-2197.2012.06233.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-2197.2012.06233.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:29:20Z","timestamp":1696462160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-2197.2012.06233.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,17]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/j.1445-2197.2012.06233.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-2197.2012.06233.x","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,17]]},"assertion":[{"value":"2012-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}