{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:46:02Z","timestamp":1788115562978,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypersplenism with thrombocytopenia is a common complication of cirrhosis with portal hypertension. We evaluated the role of splenectomy in patients with hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in terms of the improvement of biochemical indices and liver volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> underwent liver resection and splenectomy from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2000 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2009. Thirty\u2010nine patients who underwent liver resection during the same period were enrolled as case\u2010matched controls. We performed a retrospective review of prospectively collected data. We analysed the results of biochemical tests, disease\u2010free survival and overall survival and measured the liver volume before and at 90 days after operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperative white blood cell counts (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.001), platelet counts (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.021), total bilirubin (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> \u2264 0.001) and prothrombin time by international normalized ratio (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.043) were significantly different. However, these results had converged to similar levels 90 days after the operation. The degree of increment in liver volume were similar (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.763). In splenectomy group, portal vein thrombosis developed in eight patients and all patients except one recovered using only conservative treatments. There was an operative mortality because of liver failure by thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although splenectomy may induce thrombosis, liver failure and subsequent mortality, splenectomy may improve liver function and expand the indication of liver resection if postoperative management is conducted conservatively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-2197.2012.06241.x","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T02:02:15Z","timestamp":1347933735000},"page":"865-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Role of splenectomy in patients with hepatocellular carcinoma and hypersplenism"],"prefix":"10.1111","volume":"83","author":[{"given":"Sung Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Wonju Christian Hospital Yonsei University Wonju College of Medicine  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