{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:55:59Z","timestamp":1761058559297},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Bloodstream infections (BSI) occurring in community and health\u2010care settings vary with the patient group and treatment of underlying medical conditions. We studied the clinical infectious syndromes occurring in patients with positive blood cultures routinely obtained at a regional secondary and tertiary care hospital.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> BSI were categorized as either community\u2010acquired (C\u2010BSI), or health\u2010care\u2010associated (H\u2010BSI) acquired either as a (i) non\u2010inpatient (outpatient) or (ii) hospital inpatient. Clinical information was collected prospectively during the 1\u2010year study.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> There were 193 C\u2010BSI and 230 H\u2010BSI. The large majority of C\u2010BSI were caused by bacterial pathogens susceptible to narrow\u2010spectrum antibiotics, particularly in children. Cefuroxime was active against 90% of C\u2010BSI isolates and 46% of H\u2010BSI isolates, excluding anaerobes. Of all H\u2010BSI, the 35% occurring in outpatients had a similar source, microbiological cause and bacterial susceptibilities to the inpatients. H\u2010BSI were infrequently due to enterococci (4%), Candida (3%) or methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (0.4%). No BSI were due to vancomycin\u2010resistant enterococci or extended\u2010spectrum \u03b2\u2010lactamase producing Enterobacteriaciae. I.v. catheters, predominantly central lines, were the source of 60% of all H\u2010BSI, mostly in haematology\u2013oncology or neonatal patients. Mortality at 1\u2003month was 12% overall for both C\u2010BSI and H\u2010BSI, varying markedly by underlying disease and increasing age (for C\u2010BSI).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> In this population, C\u2010BSI have remained susceptible to narrow\u2010spectrum antibiotics, whereas H\u2010BSI due to multiresistant organisms were rare. Obtaining a history of recent medical procedures is important for community patients presenting with a BSI.<\/jats:p>","DOI":"10.1111\/j.1445-5994.2006.01213.x","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T16:56:14Z","timestamp":1163091374000},"page":"765-772","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Bloodstream infections in a secondary and tertiary care hospital setting"],"prefix":"10.1111","volume":"36","author":[{"given":"N. J.","family":"Raymond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Blackmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. W.","family":"Humble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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