{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:58:32Z","timestamp":1763225912173},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:00:00Z","timestamp":1300752000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of the case of a 56 year old female with sepsis on a background of rheumatoid arthritis and steroid use manifesting with overt clinical features of scurvy. Ascorbic acid assays were able to demonstrate severe deficiency and confirm a diagnosis of scurvy. Clinical resolution of signs and symptoms following commencement of vitamin C replacement was rapid. The intensivist and dietitian need to consider this diagnosis even in the first world setting, particularly in the presence of sepsis, inflammatory conditions, steroid use and importantly malnutrition.<\/jats:p>","DOI":"10.1111\/j.1445-5994.2010.02413.x","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T01:58:08Z","timestamp":1300845488000},"page":"283-285","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Scurvy: historically a plague of the sailor that remains a consideration in the modern intensive care unit"],"prefix":"10.1111","volume":"41","author":[{"given":"A. D.","family":"Holley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Osland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,22]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0903700215"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604033141407"},{"key":"e_1_2_2_4_2","first-page":"493","article-title":"Capillary hemorrhage in ascorbic\u2010acid\u2010deficient guinea pigs: ultrastructural basis","volume":"85","author":"Gone I","year":"1968","journal-title":"Arch Pathol"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2003.00637.x"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199901000-00057"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199603000-00006"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02022-5"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.5.760"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03052.x"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-35-8970P"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.48.558.243"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000247478.79779.8f"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(02)00083-5"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008026"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000174489.03363.EA"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.145"},{"key":"e_1_2_2_18_2","volume-title":"The History of Scurvy and Vitamin C","author":"Carpenter KJ","year":"1986"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350300093027"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-5994.2010.02413.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-5994.2010.02413.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:55:03Z","timestamp":1697363703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-5994.2010.02413.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1111\/j.1445-5994.2010.02413.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-5994.2010.02413.x","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"2011-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}