{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:35:14Z","timestamp":1785180914958,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T00:00:00Z","timestamp":1334275200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is an accurate and minimally invasive technique that has been shown to have excellent diagnostic yield in the investigation of mediastinal and hilar lymphadenopathy. There is, however, little evidence comparing this procedure to the traditional diagnostic approach of transbronchial lung (TBLB) and endobronchial (EB) biopsies combined with characteristic clinical and radiological features in sarcoidosis.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To compare the diagnostic yield of EBUS\u2010TBNA, TBLB and EB in patients with suspected sarcoidosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Data from 40 consecutive patients with suspected sarcoidosis who underwent combined EBUS\u2010TBNA with TBLB and EB biopsies were recorded.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 37 patients was confirmed as sarcoidosis, and three had other diagnoses. There was no difference in diagnostic accuracy rates between EBUS\u2010TBNA and TBLB for all stages of sarcoidosis (84% vs 78%, <jats:italic>P<\/jats:italic>= 0.77). Combined EBUS\u2010TBNA and TBLB procedures yielded a diagnostic accuracy of 100%. There was a highly significant difference in diagnostic accuracy between EBUS\u2010TBNA and EB in stage I (80% vs 27%) (<jats:italic>P<\/jats:italic> &lt; 0.01) and stage II disease (86% vs 27%) (<jats:italic>P<\/jats:italic> &lt; 0.01). Similarly, a highly significant difference in diagnostic accuracy was seen between TBLB and EB (<jats:italic>P<\/jats:italic> &lt; 0.01). No adverse events occurred.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Endobronchial ultrasound\u2010guided transbronchial needle aspiration alone has a high diagnostic yield with a very low complication rate for patients with suspected sarcoidosis.<\/jats:p>","DOI":"10.1111\/j.1445-5994.2011.02446.x","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T09:56:32Z","timestamp":1297158992000},"page":"434-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Diagnostic utility of endobronchial ultrasound\u2010guided transbronchial needle aspiration compared with transbronchial and endobronchial biopsy for suspected sarcoidosis"],"prefix":"10.1111","volume":"42","author":[{"given":"M.","family":"Plit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Havryk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Glanville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,13]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"736","article-title":"World association of sarcoidosis and other granulomatous disorders. Statement on sarcoidosis","volume":"160","author":"American Thoracic Society, European Respiratory Society","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197508072930603"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-1-64"},{"key":"e_1_2_6_6_2","first-page":"217","article-title":"Combining transbronchial aspiration with endobronchial and transbronchial biopsy in sarcoidosis","volume":"54","author":"Bilaceroglu S","year":"1999","journal-title":"Monaldi Arch Chest Dis"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.1.109"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.77.3.400"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.013"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1980.122.5.721"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.1.147"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262207"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10122722"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.lbr.0000210089.87086.11"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028706"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0998"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01145.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1718"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00442-4"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-5994.2011.02446.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-5994.2011.02446.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T21:15:25Z","timestamp":1697318125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-5994.2011.02446.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1445-5994.2011.02446.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-5994.2011.02446.x","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}