{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:56:05Z","timestamp":1725544565220},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Exercise\u2010induced pulmonary arterial hypertension (EIPAH) is associated with reduced peak exercise cardiac output (CO) and aerobic capacity (peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/IMJ_2501_mu1.gif\" xlink:title=\"inline image\" \/>). We investigated the validity of the encouraged 6\u2010min walk test (6MWT) to identify exercise limitation and estimate aerobic capacity in subjects with EIPAH.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seventeen subjects with EIPAH (56 \u00b1 14\u2003years, 15 women) and 20 healthy controls (57 \u00b1 13\u2003years, 19 women) underwent two encouraged 6MWTs and a symptom\u2010limited cardiopulmonary exercise test (CPET). To measure central haemodynamics, subjects with EIPAH performed the CPET with a pulmonary artery catheter <jats:italic>in situ<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with controls, subjects with EIPAH had reduced peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/IMJ_2501_mu2.gif\" xlink:title=\"inline image\" \/> (1.2 \u00b1 0.4 vs 1.7 \u00b1 0.5, L\/min, <jats:italic>P<\/jats:italic> &lt; 0.01), 6\u2010min walk distance (6MWD) (575 \u00b1 86 vs 669 \u00b1 76\u2003m, <jats:italic>P<\/jats:italic> &lt; 0.001) and 6\u2010min walk work (6MWW) (39 \u00b1 11 vs 45 \u00b1 7\u2003km.kg, <jats:italic>P<\/jats:italic> &lt; 0.01). In subjects with EIPAH, there was a moderate correlation between 6MWD and peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/IMJ_2501_mu3.gif\" xlink:title=\"inline image\" \/> (<jats:italic>r<\/jats:italic>= 0.72, <jats:italic>P<\/jats:italic> &lt; 0.01) and a strong correlation between 6MWW and peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/IMJ_2501_mu4.gif\" xlink:title=\"inline image\" \/> (<jats:italic>r<\/jats:italic>= 0.86, <jats:italic>P<\/jats:italic> &lt; 0.001). There were significant correlations between 6MWD and peak CO (<jats:italic>r<\/jats:italic>= 0.59, <jats:italic>P<\/jats:italic> &lt; 0.05), and between peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/IMJ_2501_mu5.gif\" xlink:title=\"inline image\" \/> and peak CO (<jats:italic>r<\/jats:italic>= 0.55, <jats:italic>P<\/jats:italic> &lt; 0.05). Peak heart rate was similar in the CPET and 6MWT in subjects with EIPAH (133 \u00b1 15 vs 133 \u00b1 19 beats\/min, <jats:italic>P<\/jats:italic>= 0.8).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The encouraged 6MWT identifies reduced exercise capacity and provides a valid estimate of aerobic capacity in EIPAH.<\/jats:p>","DOI":"10.1111\/j.1445-5994.2011.02501.x","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T03:18:22Z","timestamp":1302146302000},"page":"679-687","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Measurement properties of the 6\u2010min walk test in individuals with exercise\u2010induced pulmonary arterial hypertension"],"prefix":"10.1111","volume":"41","author":[{"given":"R. M.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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