{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:31:13Z","timestamp":1778895073514,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is overwhelming evidence that asthma guidelines aimed at reducing airway inflammation are superior to those based on clinical symptoms alone. This involves targeting eosinophilic inflammation with inhaled corticosteroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Because induced sputum is not readily available, our study set out to investigate whether the collective or singular use of routine asthma investigations can predict sputum eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients underwent skin prick testing, blood tests (<jats:styled-content style=\"fixed-case\">IgE<\/jats:styled-content>, full blood count), spirometry, exhaled fraction nitric oxide (<jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>15 to hypertonic saline, and induced sputum testing at first assessment. A predictive model for sputum eosinophilia (defined as \u22653% eosinophils) was sought using routinely available tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four subjects underwent both induced sputum and <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> testing. Seventeen (30%) revealed eosinophilic inflammation, nine (16%) neutrophilic, four (7%) mixed granulocytic and 26 (46%) paucigranulocytic. Positive predictors for sputum eosinophilia included low forced expiratory volume in 1\u2009s (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>)% predicted, raised serum eosinophil, positive smoking history, Polynesian ethnicity and negative asthma family history. There was a non\u2010statistically significant trend for <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> predicting sputum eosinophilia. The best combination of predictors was low <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>% predicted, raised serum eosinophil, positive smoking history and negative family history of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that the serum eosinophil count and <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> combined with aspects of a clinical history may provide a simple and practical alternative to assessment of airway (sputum) eosinophilia in the clinical setting. A full blood count can be performed at a substantially lesser cost and with greater accessibility than induced sputum. We feel the time has come for the clinical utility of the serum eosinophil count to be revisited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1445-5994.2011.02565.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T13:36:51Z","timestamp":1311687411000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Can we predict sputum eosinophilia from clinical assessment in patients referred to an adult asthma clinic?"],"prefix":"10.1111","volume":"43","author":[{"given":"E.","family":"Yap","sequence":"first","affiliation":[{"name":"Respiratory Department Middlemore Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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