{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:01:23Z","timestamp":1762542083883},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T00:00:00Z","timestamp":1334275200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 72\u2010year\u2010old female presented with a 6\u2010month history of bilateral floaters and visual blurring. Clinically, the posterior vitreous was cellular bilaterally, with no signs of subretinal infiltrates, retinal vasculitis, disc oedema or macula oedema. A vitreous biopsy and vitrectomy were scheduled following left cataract surgery because of the presence of a dense cataract. One month after cataract surgery, the patient developed signs of florid left arteritis involving the first\u2010order branches of the central retinal artery. A 23\u2010gauge vitreous biopsy and vitrectomy were performed, and preservative\u2010free triamcinolone was injected. Cytology of the biopsy demonstrated benign T\u2010lymphocytes and histiocytes suggestive of mild chronic inflammation only. Magnetic resonance imaging (MRI) of the brain was normal as was lumbar puncture. Subsequently, the patient developed right upper motor neuron facial nerve palsy. MRI imaging on this occasion demonstrated multiple hyper\u2010intense white matter lesions. A third MRI was subsequently obtained due to new neurological deficits and demonstrated enlargement of the pre\u2010existing lesions. Brain biopsy confirmed the presence of primary cerebral lymphoma. The present case highlights the role of various tissue biopsies, including vitreous, cerebrospinal fluid and brain tissue, to establish an elusive diagnosis of primary central nervous system lymphoma presenting as benign vitreous floaters.<\/jats:p>","DOI":"10.1111\/j.1445-5994.2011.02689.x","type":"journal-article","created":{"date-parts":[[2012,4,13]],"date-time":"2012-04-13T10:11:25Z","timestamp":1334311885000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary central nervous system lymphoma masquerading as bilateral vitreous floaters"],"prefix":"10.1111","volume":"42","author":[{"given":"G.","family":"Tsanaktsidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Katelaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,13]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0749-y"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01843.x"},{"key":"e_1_2_2_4_2","first-page":"5","article-title":"Intraocular lymphoma: update on diagnosis and management","volume":"11","author":"Chan CC","year":"2004","journal-title":"Cancer Control"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940903168696"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.029"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.13.524"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0031"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327672.04729.8c"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05028.x"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01125-9"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318192f574"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61416-1"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1445-5994.2011.02689.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1445-5994.2011.02689.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T21:17:12Z","timestamp":1697318232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1445-5994.2011.02689.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1445-5994.2011.02689.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1445-5994.2011.02689.x","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}