{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:07:21Z","timestamp":1776337641222,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,23]],"date-time":"2006-11-23T00:00:00Z","timestamp":1164240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> To evaluate the effect of methanol extract from the <jats:italic>Sphenocentrum jollyanum<\/jats:italic> root on male reproductive activity.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Male albino rats were treated orally with distilled water (vehicle for the extract; control) and 50, 100 and 150 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight of <jats:italic>Sphenocentrum jollyanum<\/jats:italic> root extract for 8\u00a0weeks. Each group had its own recovery. Rats were killed 24\u00a0h after the last treatment. Caudal epididymal sperm count, motility, viability, morphology and organ weights were determined. Hematological indices, serum proteins, enzymes, testicular superoxide dismutase (SOD) activity, and testicular and epididymal histology were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with the control, the extract caused a dose dependent significant (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) reduction in progressive motility of spermatozoa, viability and total sperm counts. The number of abnormal spermatozoa and epididymal volume were not statistically significant. There was a significant increase (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) in serum testosterone levels in rats treated with 50 (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01) and 100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) of <jats:italic>Sphenocentrum jollyanum<\/jats:italic>. There was a significant (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) increase in red blood cell count, packed cell volume and hemoglobin concentration, whereas there was no change in white blood cell count, mean total serum protein, albumin and globulin in the sera of <jats:italic>Sphenocentrum jollyanum<\/jats:italic> treated rats when compared with the control. The extract caused a significant decrease (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) in serum aspartate and alanine aminotransferase activities with a significant increase (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) in testicular SOD activity at a dose of 50\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> bodyweight. Testicular cytoarchitecture of the extract treated rats showed degeneration of seminiferous tubules, whereas regeneration of germinal epithelium and restructuring of the germinal interstitium occurred in the recovery rats. No lesions were observed in the epididymis of the rats.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results suggest that methanol extract of the <jats:italic>Sphenocentrum jollyanum<\/jats:italic> root could produce harmful effects on reproductive functions in male albino rats which can be attributed to poor sperm quantity (epididymal sperm count), quality (sperm motility, viability and morphology) and testicular degeneration. The steroidogenic potential of the plant could explain its use as an aphrodisiac agent. (Reprod Med Biol 2006; <jats:bold>5<\/jats:bold>: 283\u2013292)<\/jats:p>","DOI":"10.1111\/j.1447-0578.2006.00154.x","type":"journal-article","created":{"date-parts":[[2006,11,23]],"date-time":"2006-11-23T09:34:12Z","timestamp":1164274452000},"page":"283-292","source":"Crossref","is-referenced-by-count":11,"title":["Comprehensive assessment of the effect of <i>Sphenocentrum jollyanum<\/i> root extract on male reproductive activity in albino rats"],"prefix":"10.1002","volume":"5","author":[{"given":"YINUSA","family":"RAJI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLAYEMI O.","family":"FADARE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAHMAT A.","family":"ADISA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAKIRU A.","family":"SALAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365215"},{"key":"e_1_2_5_3_2","unstructured":"World Health Organisation. Report of task force on antifertility plants especially from tropical forests.WHO Geneva Switzerland 1981."},{"key":"e_1_2_5_4_2","unstructured":"DazielJM. The useful plants of West Tropical Africa.Crown Agents London 1937;264."},{"key":"e_1_2_5_5_2","unstructured":"IwuMM. Handbook of African Medicinal Plants.CRC Press Boca Raton 1993;116\u2013118."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958044"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00615-2"},{"key":"e_1_2_5_8_2","unstructured":"RajiY OdukanmiA OlaleyeSB OnasanwoSA SalamiSA BolarinwaAF Quassin: The antianaemic principle ofQuassia amaraextract.Pakist J Biol Sci2006(in press)."},{"key":"e_1_2_5_9_2","first-page":"159","article-title":"Implication of reproductive endocrine malfunction in male antifertility efficacy of Azadirachta indica extract in rats","volume":"32","author":"Raji Y","year":"2003","journal-title":"J Med Med Sci"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2005.00051.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00055.x"},{"key":"e_1_2_5_12_2","first-page":"9","article-title":"In vivo and in vitro reproductive toxicity assessment of ampicillin and cloxacillin in mammalian models","volume":"2","author":"Raji Y","year":"2006","journal-title":"Int Jour Pharmcolo"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6510.1693"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.suppl_1.15"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56895-2"},{"key":"e_1_2_5_16_2","first-page":"77","article-title":"Screening of some Nigerian medicinal plants for antioxidant activity using 2.2 diphenyl. picryl hydrazyl radical","volume":"5","author":"Oke JM","year":"2002","journal-title":"Afri Biome Res"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi971894b"},{"key":"e_1_2_5_18_2","volume-title":"Emergency Medicine","author":"Williams GD","year":"2002"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00080-1"},{"key":"e_1_2_5_20_2","first-page":"117","volume-title":"Textbook of Physiology and Biochemistry","author":"Bell GH","year":"1972"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02801.x"},{"key":"e_1_2_5_22_2","first-page":"105","article-title":"The effects of bilateral orchidectomy on some serum enzymes and proteins in the West African Dwarf Buck","volume":"3","author":"Oyeyemi MO","year":"2000","journal-title":"Afri Jour Biome Res"},{"key":"e_1_2_5_23_2","first-page":"129","article-title":"Evaluation of the anti\u2010oxidant and anti\u2010angiogenic effects of Sphenocentrum Jollyanum Pierre","volume":"7","author":"Nia R","year":"2004","journal-title":"Afri Jour Biome Res"},{"issue":"2","key":"e_1_2_5_24_2","first-page":"105","article-title":"Reproductive functions in male rats treated with methanolic extract of Alstonia boonei stem bark","volume":"8","author":"Raji Y","year":"2005","journal-title":"Afr Biomed Res"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)00305-0"},{"key":"e_1_2_5_26_2","first-page":"3557","article-title":"Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis","volume":"59","author":"Meistrich ML","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018905403359"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0578.2006.00154.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0578.2006.00154.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0578.2006.00154.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:28:14Z","timestamp":1696876094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0578.2006.00154.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,23]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1447-0578.2006.00154.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0578.2006.00154.x","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,23]]}}}