{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:24:10Z","timestamp":1789932250716,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> Although several studies have reported various causes of ischemic stroke in patients with cancer, only a few have evaluated the clinical relevance of ischemic stroke pathogenesis to cancer. The aim of the present study was to elucidate the clinical characteristics of cancer\u2010associated ischemic stroke.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> We evaluated 154 ischemic stroke patients without cancer and 57 ischemic stroke patients with cancer who had either received continuous treatment for cancer within 5\u2003years before to the onset of ischemic stroke, or who had been diagnosed with cancer within 1\u2003year after the onset of ischemic stroke. Cancer patients were grouped into \u201ccancer\u2010associated ischemic stroke,\u201d the \u201cconventional ischemic stroke,\u201d or \u201cother.\u201d<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> A total of 15 patients (26%) were classified into the cancer\u2010associated ischemic stroke in cancer patients. In univariate analysis of the cancer\u2010associated ischemic stroke and the others, there were significant differences in the prevalence of hypertension, hyperlipidemia and advanced cancer (clinical stage\u2003IV), and the levels of <jats:sc>d<\/jats:sc>\u2010dimer, fibrin degradation product and hemoglobin. With multivariate regression analysis of those factors, the prevalence of hypertension, hyperlipidemia and advanced cancer (clinical stage IV), and the levels of <jats:sc>d<\/jats:sc>\u2010dimer and fibrin degradation product remained as statistically independent factors, which were associated with cancer\u2010associated ischemic stroke (<jats:italic>n<\/jats:italic>\u2003=\u2003111, \u03c7<jats:sup>2<\/jats:sup>\u2003=\u200367.21, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001).<\/jats:p><jats:p><jats:bold>Conclusion:\u2003<\/jats:bold> In acute ischemic stroke, the cancer\u2010associated ischemic stroke is associated with elevated <jats:sc>d<\/jats:sc>\u2010dimer and fibrin degradation products, even after controlling hypertension, hyperlipidemia and advanced cancer (clinical stage\u2003IV). <jats:bold>Geriatr Gerontol Int 2012; 12: 468\u2013474.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1447-0594.2011.00796.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T12:18:47Z","timestamp":1326197927000},"page":"468-474","source":"Crossref","is-referenced-by-count":47,"title":["Cancer\u2010associated ischemic stroke is associated with elevated <scp>d<\/scp>\u2010dimer and fibrin degradation product levels in acute ischemic stroke with advanced cancer"],"prefix":"10.1111","volume":"12","author":[{"given":"Tomoyuki","family":"Kono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiho","family":"Ohtsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Sueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemori","family":"Yamawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayasu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198501000-00002"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-002-0009-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(02)00066-X"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129912.56486.2B"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22050"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000131269.69502.d9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571356"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.09.140"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9903-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000316764"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.4.522"},{"key":"e_1_2_7_15_2","first-page":"646","article-title":"Mucin and fat emboli in mucinous carcinomas. Cause of hemorrhagic cerebral infarcts","volume":"107","author":"Towfighi J","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801001)46:7<1608::AID-CNCR2820460720>3.0.CO;2-X"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0594.2011.00796.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0594.2011.00796.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:40:46Z","timestamp":1697348446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0594.2011.00796.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1447-0594.2011.00796.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0594.2011.00796.x","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}