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The binding motifs and potential functions of 14\u20103\u20103 proteins are now recognized to have a wide range of functional relevance. First, we provide a brief summary of the molecular structure and multiple functions of 14\u20103\u20103 proteins. Second, we review the involvement of 14\u20103\u20103 proteins in common diseases of geriatric neurology, such as Alzheimer's disease and tauopathies, Parkinson's disease and \u03b1\u2010synucleinopathies, Huntington's disease and polyglutamine diseases, Creutzfeldt\u2013Jakob disease and prion diseases, cerebral infarction, and atherosclerosis. Finally, we discuss the immunohistochemical localization of 14\u20103\u20103 proteins and its isoforms during the postnatal development of rat brains as a basis for understanding adult neurogenesis. The elucidation of the isoform\u2010dependent functions of 14\u20103\u20103 proteins with regard to brain development might be promising for the future development of novel therapeutic interventions for common diseases of geriatric neurology. <jats:bold>Geriatr Gerontol Int 2012; \u2022\u2022: \u2022\u2022\u2013\u2022\u2022.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1447-0594.2012.00860.x","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T19:24:58Z","timestamp":1338837898000},"page":"586-599","source":"Crossref","is-referenced-by-count":9,"title":["Structure\u2010oriented review of 14\u20103\u20103 protein isoforms in geriatric 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