{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:28:00Z","timestamp":1777523280944,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p><jats:bold>Aim:\u2003<\/jats:bold> Serum parathyroid hormone (PTH) and 25\u2010hydroxyvitamin D (25OHD) concentrations might contribute to blood pressure (BP) levels. Mixed results in previous literature could be due to the failure to consider both these hormones concurrently, despite their long\u2010known relationship. Our objective was to examine the association of serum intact PTH and 25OHD concentrations with BP levels amongst older inpatients, while accounting for each other.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> The participants were 284 Caucasian older inpatients with no suspicion of primary hyperparathyroidism (mean age 85.87\u2003\u00b1\u20035.90 years; 65.8% female) admitted to the geriatric acute care unit of Angers University Hospital, France. They were divided into two groups according to the existence of hypertension (i.e. systolic blood pressure [SBP] &gt;140\u2003mmHg, or diastolic blood pressure [DBP] &gt;90\u2003mmHg). Age, sex, numbers of chronic diseases and of drugs taken daily, use of antihypertensive or corticosteroid drugs and of calcium supplements\/vitamin D, thyroid\u2010stimulating hormone and albumin concentrations, creatinine clearance, and season tested were used as covariables.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> Hypertensive participants (<jats:italic>n<\/jats:italic>\u2003=\u2003106) had higher intact PTH concentrations than normotensive patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.044). There was a positive linear association of BP with intact PTH concentrations (adjusted \u03b2\u2003=\u20030.08, <jats:italic>P<\/jats:italic>\u2003=\u20030.015 for SBP; adjusted \u03b2\u2003=\u20030.05, <jats:italic>P<\/jats:italic>\u2003=\u20030.044 for DBP), but not with vitamin D. Serum intact PTH concentration, unlike 25OHD, was associated with hypertension (adjusted OR 1.01, <jats:italic>P<\/jats:italic>\u2003=\u20030.038).<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> Irrespective of 25OHD, PTH was associated with hypertension by increasing both SBP and DBP. <jats:bold>Geriatr Gerontol 2013; 13: 783\u2013791<\/jats:bold>.<\/jats:p>","DOI":"10.1111\/j.1447-0594.2012.00945.x","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T02:01:16Z","timestamp":1348106476000},"page":"783-791","source":"Crossref","is-referenced-by-count":16,"title":["High parathyroid hormone, but not low vitamin D concentrations, expose elderly inpatients to hypertension"],"prefix":"10.1111","volume":"13","author":[{"given":"Leyla","family":"Mateus\u2010Hamdan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Bouvard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Legrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Fantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Annweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.329"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555253"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199800001-00042"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000179764.40701.36"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01778.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(94)00195-H"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"e_1_2_7_10_2","first-page":"259","article-title":"Vitamin D in the elderly: 5 points to remember","volume":"9","author":"Annweiler C","year":"2011","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01487.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410350"},{"key":"e_1_2_7_13_2","first-page":"113","article-title":"Relationship between abnormal regulation of cytoplasmic calcium and elevated blood pressure in patients with primary hyperparathyroidism","volume":"8","author":"Lind L","year":"1994","journal-title":"J Hum Hypertens"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.024"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/309068"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/974647"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199012000-00017"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282ffb43b"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.4.468"},{"key":"e_1_2_7_20_2","first-page":"1356","article-title":"Effect of PTH(1\u201034) on blood pressure, renal function, and hormones in essential hypertension. The altered pattern of reactivity may counteract raised blood pressure","volume":"10","author":"Jespersen B","year":"1997","journal-title":"Am J Hypertens"},{"key":"e_1_2_7_21_2","first-page":"360","article-title":"Chronic continuous PTH infusion results in hypertension in normal subjects","volume":"2","author":"Hulter HN","year":"1986","journal-title":"J Clin Hypertens"},{"key":"e_1_2_7_22_2","first-page":"77","article-title":"Hypertension and primary hyperparathyroidism: the role of adrenaline and renin\u2010angiotensin systems","volume":"21","author":"Gennari C","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.988"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.041"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118368"},{"key":"e_1_2_7_26_2","first-page":"87A","article-title":"Involvement of endothelium in contractile response of resistance arteries in parathyroidectomized SHR","volume":"3","author":"Schlieffer R","year":"1990","journal-title":"Am J Hypertens"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00130-9"},{"key":"e_1_2_7_28_2","first-page":"S155","article-title":"Parathyroid hypertensive factor","volume":"8","author":"Pang PK","year":"1990","journal-title":"J Hypertens"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000192025.86189.46"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.2.2.162"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1080S"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215219"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706127"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-5-201003020-00009"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832f075b"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1993.sp003687"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl443"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2006.05180.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117741"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0594.2012.00945.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0594.2012.00945.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:21:56Z","timestamp":1696328516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0594.2012.00945.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,19]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/j.1447-0594.2012.00945.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0594.2012.00945.x","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,19]]}}}