{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T23:11:12Z","timestamp":1723331472477},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> This prospective, single\u2010blind and controlled clinical study aimed to research if CA\u2010125 levels could be a useful test in the differential diagnosis of intact and ruptured tubal ectopic pregnancy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty\u2010five women with tubal ectopic pregnancy of 5\u201310\u2003weeks\u2019 duration (27 women with ruptured tubal ectopic pregnancy [REP] and 38 women with unruptured tubal ectopic pregnancy [UREP]) and 65 women with normal intrauterine pregnancy (NIUP) of the same gestational age were studied prospectively. Serum CA\u2010125 levels were measured in all women and these levels were compared among the REP, UREP, and NIUP groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean CA\u2010125 levels didn\u2019t show any significant difference between the REP and NIUP groups (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). The mean CA\u2010125 levels of these two groups were higher than that in the UREP group (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001, respectively). The dispersion ratios of the CA\u2010125 levels had a statistically significant difference between the REP and UREP groups (\u03c7<jats:sup>2<\/jats:sup>: 42.44, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). CA\u2010125 levels weren\u2019t correlated with gestational weeks in the REP and UREP groups (r: 0.005, <jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05; r: 0.008, <jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05, respectively).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In intact tubal ectopic pregnancies, expectant or managed with medical treatment, the increase of CA\u2010125 levels in the serial measurements could be a supplementary test for an early diagnosis of tubal rupture.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2006.00424.x","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T10:32:35Z","timestamp":1153132355000},"page":"422-427","source":"Crossref","is-referenced-by-count":11,"title":["CA\u2010125 levels in ruptured and unruptured tubal ectopic pregnancies"],"prefix":"10.1111","volume":"32","author":[{"given":"Erdal","family":"Malatyalioglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Kokcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet B.","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayfun","family":"Alper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Migraci","family":"Tosun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00533-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00554-3"},{"key":"e_1_2_5_4_2","first-page":"149","article-title":"The hormonal profile in ectopic pregnancies","volume":"25","author":"Kuscu E","year":"1993","journal-title":"Mater Med Pol"},{"key":"e_1_2_5_5_2","first-page":"875","article-title":"Serum CA\u2010125 levels in women with ectopic and intrauterine pregnancies","volume":"36","author":"Sadovsky Y","year":"1991","journal-title":"J Reprod Med"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000293647"},{"key":"e_1_2_5_7_2","first-page":"499","article-title":"Serum concentration of CA\u2010125 during the first trimester of normal and abnormal pregnancies","volume":"35","author":"Brumsted JR","year":"1990","journal-title":"J Reprod Med"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06798.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(89)80027-4"},{"key":"e_1_2_5_10_2","first-page":"703","article-title":"CA 125 antigen levels in obstetrics and gynecologic patients","volume":"64","author":"Niloff JM","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02426356"},{"key":"e_1_2_5_12_2","first-page":"742","article-title":"Serum CA\u2010125 levels in early pregnancy and subsequent spontaneous abortion","volume":"75","author":"Check JH","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90202-0"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1447-0756.2006.00424.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1447-0756.2006.00424.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:43:50Z","timestamp":1696880630000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1447-0756.2006.00424.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,17]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1447-0756.2006.00424.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1447-0756.2006.00424.x","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,17]]}}}