{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:39:38Z","timestamp":1791225578333,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold>To investigate the association between aquaporin\u20108 (AQP\u20108: a water channel protein) expression in fetal membranes and oligohydramnios during near\u2010term and postdate pregnancy, we set up an oligohydramnios model using prostaglandin F2\u03b1 receptor (FP)\u2010deficient mice.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Pregnant FP\u2010deficient mice from 14 to 21 gestational days (GD) were killed to measure the amniotic fluid volume (AFV), and fetal membranes were collected for the analysis of aquaporin\u20108 expression.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>The AFV was highest at 14\u2003GD, and was significantly decreased to 28% and 0% at 20\u2003GD and 21\u2003GD, respectively, compared with the volume at 14\u2003GD. Immunohistochemistry and immunoblot analysis showed that aquaporin\u20108 was expressed in the basal component of fetal membranes, and that the protein level was significantly decreased to 60% at 20\u2003GD compared with that at 14\u2003GD.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>We demonstrated that AQP\u20108 expression in the fetal membrane was decreased at post term in FP\u2010deficient mice. Our findings suggest that aquaporin\u20108 in fetal membranes may be involved in the regulation of AFV, especially when oligohydramnios occurs.<\/jats:p>","DOI":"10.1111\/j.1447-0756.2006.00425.x","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T10:32:35Z","timestamp":1153132355000},"page":"373-378","source":"Crossref","is-referenced-by-count":12,"title":["Reduction of aquaporin\u20108 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2\u03b1 receptor"],"prefix":"10.1111","volume":"32","author":[{"given":"Mitsunori","family":"Shioji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Wasada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kanagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Shimoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"827","volume-title":"Medicine 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